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Cited by 33Advanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

In vivo whole-brain T1-rho mapping across adulthood: normative values and age dependence

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Watts, Richard, Andrews, Trevor, Hipko, Scott, Gonyea, Jay V., Filippi, Christopher G.·2014·Journal of Magnetic Resonance Imaging
DOI 10.1002/jmri.24358
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Abstract

Purpose: To report a systematic investigation of variations in brain T 1ρ (T1‐rho) values over adulthood, and present normative values for cortical gray matter, juxtacortical white matter, selected white matter tracts and subcortical structures. Materials and Methods: Forty‐one healthy control subjects (23 males aged 18–76 years and 18 females aged 21–73 years) were imaged at 3.0 Tesla (T) using a novel whole‐brain T 1ρ‐weighted fluid suppressed three‐dimensional turbo spin echo technique. T 1ρ maps were calculated and atlas‐based segmentation used to determine regional T 1ρ values. Linear regression was used to determine changes in T 1ρ with age. Results: T 1ρ values showed significant decreases with age in cortical gray matter (P < 0.001), left and right caudate (P = 0.004/0.006), putamen (P = 0.001, P < 0.001), hippocampus (P = 0.039/0.010), amygdala (P = 0.002/0.001), and nucleus accumbens (P = 0.001/0.002). Significant increases with age (P < 0.05) were observed in all the white matter tracts considered, except the corticospinal tracts and forceps major. Conclusion: T 1ρ demonstrates changes related to the processes of normal aging. J. Magn. Reson. Imaging 2014;40:376–382. © 2013 Wiley Periodicals, Inc.

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  • Watts et al. found ~7-10% lower T1ρ value both in GM and WM compared to the current study.

    “In addition, Watts et al. have found ~7–10% lower T1ρ value both in GM and WM compared to the current study.”

    From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Watts et al., 2014

    Table 1 (page not provided) reports mean T1ρ values for cortical GM and for juxtacortical WM and major WM tracts. The paper does not give the citing study’s values, so its text cannot establish that these measurements are approximately 7–10% lower. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Watts et al. observed a positive correlation between WM T1ρ and age while GM T1ρ showed negative correlation with age.

    “Recently, Watts et al., have evaluated the age dependence changes in GM and WM T1ρ relaxation times in brain of normal human volunteers on a 3-T MRI scanner (Watts et al., 2014). They have observed a positive correlation between WM T1ρ and age while the GM T1ρ showed negative correlation with age.”

    From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Watts et al., 2014

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Cited by

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Authors
Watts, R., Andrews, T., Hipko, S., Gonyea, J. V., & Filippi, C. G.
Affiliations
University of Vermont (US)
Corresponding author
Watts, Richard
ORCID
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2013-11-13
Volume
40
Issue
2
Pages
376-382
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
DOI
10.1002/jmri.24358
OpenAlex
W1768199660
Cited by
33
References
1
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5
FWCI
2.33
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Department of Energy (DESC0001753)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
T1rho mapping, brain aging, reference values, cortical gray matter, white matter tracts, caudate nucleus, putamen, hippocampus, amygdala, nucleus accumbens, age-related changes
MeSH terms
Adolescent, Adult, Aged, Aging, Brain, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Sensitivity and Specificity, Reproducibility of Results

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