The DOI matches its Crossref record; 20 of the 22 references it cites were found in a registry or an index.
The behaviour of recent isolates of human respiratory coronavirus in vitro and in volunteers: evidence of heterogeneity among 229E-related strains
Open accessAbstract
Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains were serologically related to 229E, but these isolates produced colds with a frequency and severity that contrasted with the effects of 229E itself. Tests on volunteers' preinfection sera showed that the prevalence of antibody to 229E had increased during the period 1961–1979 and that during 1977–1979 only 11% of subjects had no neutralising antibody against 229E. Susceptibility to the 229E‐related isolates PR and TO was associated with low preinfection serum neutralising antibody against the homologous virus, and paired sera frequently showed fourfold or greater antibody rises, most commonly against the homologous strain. Volunteers infected with TO were immune when reinoculated with the same strain approximately 1 year later, but other similar volunteers were at least partly susceptible to infection with a heterologous 229E‐related virus after similar time intervals. Although the strains of HCV that were grown in tissue culture were all related to the prototype 229E, they appeared not to be identical with it, and this heterogeneity is probably a significant factor in the epidemiology of HCV infections.
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“Thus, the studies provide evidence for immune memory that at least provided protection from clinical symptoms and reduced viral shedding; this also provides support for the potential efficacy of a SARS-CoV-2 vaccine.”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Reed, 1984
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Cites
A New Virus Isolated from the Human Respiratory Tract.
Hamre, D. M., & Procknow, J. J. (1966) · Experimental Biology and Medicine · doi:10.3181/00379727-121-30734 · Cited by 888
Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease.
McIntosh, K., Dees, J. H., Becker, W. B., Kapikian, A. Z., & Chanock, R. M. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.4.933 · Cited by 589
Effects of a "new" human respiratory virus in volunteers.
Bradburne, A. F., Bynoe, M. L., & Tyrrell, D. A. J. (1967) · BMJ · doi:10.1136/bmj.3.5568.767 · Cited by 304
Almeida, J. D., & Tyrrell, D. A. J. (1967) · Journal of General Virology · doi:10.1099/0022-1317-1-2-175 · Cited by 275
Coronaviruses: A Comparative Review
McIntosh, K. (1974) · Springer eBooks · doi:10.1007/978-3-642-65775-7_3 · Cited by 270
Isolation of rhinoviruses and coronaviruses from 38 colds in adults
Larson, H. E., Reed, S. E., & Tyrrell, D. A. J. (1980) · Journal of Medical Virology · doi:10.1002/jmv.1890050306 · Cited by 168
Self-citationThe Structure and Replication of Coronaviruses
Siddell, S. G., Wege, H., & ter Meulen, V. (1982) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-68528-6_4 · Cited by 136
Darbyshire, J. H., Rowell, J. G., Cook, J. K. A., & Peters, R. W. (1979) · Archives of Virology · doi:10.1007/bf01318057 · Cited by 133
Coronavirus infections in working adults. Eight-year study with 229 E and OC 43.
Hendley, J. O., Fishburne, H. B., & Gwaltney, J. M. (1972) · PubMed · doi:10.1164/arrd.1972.105.5.805 · Cited by 118
Medical reviews. Coronaviruses.
Monto, A. S. (1974) · PubMed Central · Cited by 98
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- Hendley JO, 1972, Coronavirus infections in working adults: Eight year study with 229E and OC43, American Review of Respiratory Disease, 105, 805
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Metadata
- Authors
- Reed, S. E.
- Affiliations
- Medical Research Council (GB)
- Corresponding author
- Reed, Sylvia E.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 1984-01
- Volume
- 13
- Issue
- 2
- Pages
- 179-192
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC7166702
- OpenAlex
- W2029391755
- Cited by
- 147
- References
- 22
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 36 · 2020: 36 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- 229E, cold, serological relatedness, neutralizing antibodies, antibody response, reinfection
- MeSH terms
- Adolescent, Adult, Antibodies, Viral, Antigens, Viral, Cell Line, Common Cold, Coronaviridae, Coronaviridae Infections, Humans, Middle Aged, Neutralization Tests, Viral Plaque Assay
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