HTLV‐I infection in patients with autoimmune thyroiditis (Hashimoto's thyroiditis)
Abstract
To investigate the possible relationship of HTLV‐I virus infection to autoimmune thyroid disease, we examined, firstly, the frequency of HTLV‐I seropositivity among patients with Hashimoto's thyroiditis and, secondly, the frequency of Hashimoto's thyroiditis in patients with HTLV‐I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Of 144 patients with Hashimoto's thyroiditis in the Tokushima and Kochi Prefectures, Japan, 9 (6.3%) were positive for serum HTLV‐I virus antibody 2 of whom were confirmed histologically to have Hashimoto's thyroiditis. This percentage is significantly higher (P < 0.01) than the estimated prevalence (2.2%) of HTLV‐I carriers among the general population in this region. Of 9 patients with HAM/TSP, 3 (33.3%), including 2 biopsy‐proven cases, had evidence of Hashimoto's thyroiditis. This proportion is apparently much higher than the prevalence (1.7%) of Hashimoto's thyroiditis in the general population. These findings suggest that HTLV‐I virus may be related to the development of Hashimoto's thyroiditis. © 1992 Wiley‐Liss, Inc.
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HTLV-1 infection is associated with a range of other inflammatory diseases and infections.
“HTLV-1 infection is also associated with a range of other inflammatory diseases and infections.”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [98]
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References 22 · Cited by 65
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- Authors
- Kawai, H., Inui, T., Kashiwagi, S., Tsuchihashi, T., Masuda, K., Kondo, A., Niki, S., Iwasa, M., & Saito, S.
- Affiliations
- Tokushima University (JP)
- Tokushima Hospital (JP)
- Corresponding author
- Kawai, H.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 1992-10
- Volume
- 38
- Issue
- 2
- Pages
- 138-141
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W2072367920
- Cited by
- 65
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Keywords
- HTLV-1 infection, Hashimoto's thyroiditis, autoimmune thyroid disease, HAM/TSP, HTLV-1-associated myelopathy/tropical spastic paraparesis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Epidemiologic Methods, Female, Humans, Japan, Male, Middle Aged, Thyroiditis, Autoimmune, HTLV-I Antibodies, HTLV-I Infections, Paraparesis, Tropical Spastic
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