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Benign human enterovirus becomes virulent in selenium‐deficient mice
Abstract
Coxsackieviruses have been implicated as possible co‐factors in the etiology of the selenium (Se)‐responsive cardiomyopathy known as Keshan disease. Here we report that a cloned and sequenced amyocarditic coxsackievirus B3 (CVB3/0), which causes no pathology in the hearts of Se‐adequate mice, induces extensive cardiac pathology in Se‐deficient mice. CVB3/0 recovered from the hearts of Se‐deficient mice inoculated into Se‐adequate mice induced significant heart damage, suggesting mutation of the virus to a virulent genotype. We demonstrate the important role of host nutritional status in determining the severity of a viral infection. © 1994 Wiley‐Liss, Inc.
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Cited by
Selenium in global food systems
Combs, G. F. (2001) · British Journal of Nutrition · doi:10.1079/bjn2000280 · Cited by 1,129
Beck, M. A., Shi, Q., Morris, V. C., & Levander, O. A. (1995) · Nature Medicine · doi:10.1038/nm0595-433 · Cited by 384
Self-citationKashin–Beck Osteoarthropathy in Rural Tibet in Relation to Selenium and Iodine Status
Moreno-Reyes, R., Suetens, C., Mathieu, F., Begaux, F., Zhu, D., Rivera, M. T., Boelaert, M., Nève, J., Perlmutter, N., & Vanderpas, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810153391604 · Cited by 317
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147
Metadata
- Authors
- Beck, M. A., Kolbeck, P. C., Rohr, L. H., Shi, Q., Morris, V. C., & Levander, O. A.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 1994-06
- Volume
- 43
- Issue
- 2
- Pages
- 166-170
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W1973809950
- Cited by
- 182
- References
- 0
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beck, M. A., Kolbeck, P. C., Rohr, L. H., Shi, Q., Morris, V. C., & Levander, O. A. (1994). Benign human enterovirus becomes virulent in selenium‐deficient mice. Journal of Medical Virology. https://doi.org/10.1002/jmv.1890430213
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