Serological tests facilitate identification of asymptomatic SARS‐CoV‐2 infection in Wuhan, China
Open accessAbstract
Till April 15, 2020, 83 745 confirmed cases and 3352 deaths related to coronavirus disease, 2019 (COVID-19) were reported in mainland China. Among them, 50 008 confirmed cases and 2579 deaths were from Wuhan alone. Wuhan has been sealed off since January 23, along with 16 of its neighboring cities in Hubei province included, to contain the spread of COVID-19. The institution of interventions including cordons sanitaire, traffic restriction, social distancing, home quarantine, centralized quarantine, and universal symptom survey contributed largely to the reduced spread of SARS-CoV-2.1 The effective reproduction number of SARS-CoV-2 fluctuated above 3.0 before January 26 but decreased to less than 0.3 after March 1. Wuhan City has lifted the lockdown and people have been allowed to resume working since April 8, 2020. A set of COVID-19-associated tests is required before resuming, including SARS-CoV-2 nucleic acid test (NAT) of nasopharyngeal swabs, chest computed tomography (CT) scan or a SARS-CoV-2-specific serological test.2, 3 These tests are presumed to identify COVID-19 patients or asymptomatic SARS-CoV-2 infections.3, 4 As few confirmed cases were found in Wuhan after April 8, it is essential to investigate the positive rate of this "tests for resume", which might help in evaluation, to some degree, of the herd immunity of the city. Here, we report the positive rate of COVID-19 tests based on NAT, chest CT scan and serological SARS-CoV-2 test, from April 3 to 15 in a hos…
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At the release of lockdown in Wuhan, 9.6% of staff resuming work were found to have antibodies to SARS-CoV-2.
“For example, at the release of lockdown in Wuhan, 9.6% of staff resuming work were found to have antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (8).”
From Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors (2021) · cites this paper as [8]
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- Authors
- Wu, X., Fu, B., Chen, L., & Feng, Y.
- Affiliations
- Department of Respiratory and Critical Care Medicine CR & WISCO General Hospital Wuhan Hubei China
- Department of Clinical Laboratory CR & WISCO General Hospital Wuhan Hubei China
- Wuhan University (CN)
- Corresponding author
- Feng, Yong
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2020-06-24
- Volume
- 92
- Issue
- 10
- Pages
- 1795-1796
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC7264791
- OpenAlex
- W3016977245
- Cited by
- 87
- References
- 4
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 21 · 2021: 17 · 2020: 43
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81471940)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, asymptomatic infection, serological testing, nucleic acid testing, chest CT, herd immunity, hospital reopening, Wuhan, seroprevalence, pre-employment screening, SARS-CoV-2 antibodies, SARS-CoV-2 RNA
- MeSH terms
- COVID-19, SARS-CoV-2, China, Female, Humans, Middle Aged, Pneumonia, Viral, Serologic Tests, Asymptomatic Infections, Pandemics
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