The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Long‐term variations and potency of neutralizing antibodies against Omicron subvariants after CoronaVac‐inactivated booster: A 7‐month follow‐up study
Open accessAbstract
The long-term protective efficacy of neutralizing antibodies (Nabs) against Omicron subvariants after inactivated booster vaccines remains elusive. During the follow-up study, 54 healthy volunteers aged 20-31 years received inactivated CoronaVac booster vaccinations and were monitored for 221 days. The dynamic efficacy and durability of Nab against Omicron subvariants BA.1, BA.2, BA.2.12.2, and BA4/5 were assessed using a pseudotyped virus neutralization assay at up to nine time points post immunization. The antibody response against Omicron subvariants was substantially weaker than D614G, with BA.4/5 being the least responsive. The geometric mean titer (GMT) of Nab against Omicron subvariants BA.1, BA.2, BA.2.12.1, and BA.4/5 was 2.2-, 1.7-, 1.8-, and 2.2-fold lower than that against D614G (p s s 50 ]), whereas at 77.3% for BA.1, 90.9% for BA.2, 86.4% for BA.2.12.1, and 86.4% for BA.4/5 (almost 20% for Nab titers ≥ 100 EC 50 ). Despite the inevitable immune escape, Omicron subvariants maintained sustained and measurable antibody potency post-booster vaccination during long-term monitoring, which could help optimize immunization strategies.
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Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2
Nie, J., Li, Q., Wu, J., Zhao, C., Hao, H., Liu, H., Zhang, L., Nie, L., Qin, H., Wang, M., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1743767 · Cited by 711
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Lau, J. J., Cheng, S. M. S., Leung, K., Lee, C. K., Hachim, A., Tsang, L. C. H., Yam, K. W. H., Chaothai, S., Kwan, K. K. H., Chai, Z. Y. H., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02219-5 · Cited by 198
Metadata
- Authors
- Li, X., Yin, Y., Cui, Q., Huang, W., Zou, Q., & Shen, T.
- Affiliations
- Peking University (CN)
- National Medical Products Administration (CN)
- Corresponding author
- Zou, Qinghua
- Shen, Tao
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2022-11-11
- Volume
- 95
- Issue
- 1
- Pages
- e28279-e28279
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC9877893
- OpenAlex
- W4308179383
- Cited by
- 4
- References
- 1
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Beijing Municipality (M21021)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- neutralizing antibodies, Omicron subvariants, CoronaVac, SARS-CoV-2, BA.1, BA.2, antibody persistence, immune evasion, vaccine potency, long-term antibody response
- MeSH terms
- COVID-19 Vaccines, Antibodies, Viral, Biological Assay, Follow-Up Studies, Humans, Immunization, Vaccines, Inactivated, Antibodies, Neutralizing
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