The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Effect of hypoglycemia on brain glycogen metabolism in vivo
Open accessAbstract
The brain contains a small but significant amount of glycogen, which has long been considered to play an insignificant role in the brain. In this study, brain glycogen metabolism was measured using 13 C NMR spectroscopy at 9.4 T. Brain glycogen metabolism was modulated by hyperinsulinemia resulting in a net accumulation. The role of glycogen in maintaining brain function is unknown; one possibility is that it may serve as an endogenous glucose reservoir to protect the brain against severe hypoglycemia. To address this possibility, rats were subjected to insulin‐induced moderate hypoglycemia and when the level of brain glucose approached zero, brain glycogen content began to decrease gradually, demonstrating utilization of this glucose reservoir. The brain glycogen signal never became undetectable, however, even during 2 hr of hypoglycemia. When plasma and brain glucose concentrations were restored, glycogen increased and the concentration exceeded the pre‐hypoglycemic level by several‐fold. The data suggest that brain glycogen can provide fuel for extended periods of time when glucose supply is inadequate. Furthermore, brain glycogen can rebound (super‐compensate) after a single episode of hypoglycemia. We postulate that brain glycogen serves as an energy store during hypoglycemia and that it may participate in the creation of reduced physiological responses to hypoglycemia that are involved in a symptom often observed in patients with diabetes, hypoglycemia unawareness. © 2003 Wiley‐Liss, Inc.
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Mitrakou, A., Ryan, C., Veneman, T., Mokan, M., Jenssen, T., Kiss, I., Durrant, J., Cryer, P., & Gerich, J. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.1.e67 · Cited by 558 · cited 1×
“When a sudden fall in plasma glucose occurs, the brain is protected normally against hypoglycemia through a number of autonomic counterregulatory responses, including the inhibition of insulin secretion and the sequential release of glucagon, epinephrine, norepinephrine, cortisol (ACTH) and growth hormone (Gerich et a…”
BackgroundA mathematical model of compartmentalized neurotransmitter metabolism in the human brain
Gruetter, R., Seaquist, E. R., & Ugurbil, K. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e100 · Cited by 326
Self-citationHypoglycemia: The Limiting Factor in the Management of IDDM
Cryer, P. E. (1994) · Diabetes · doi:10.2337/diab.43.11.1378 · Cited by 307
Kong, J., Shepel, P. N., Holden, C. P., Mackiewicz, M., Pack, A. I., & Geiger, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05581.2002 · Cited by 281
Glucose, exercise and insulin: emerging concepts
Richter, E. A., Derave, W., & Wojtaszewski, J. F. P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-2-00313.x · Cited by 258
Adaptation in brain glucose uptake following recurrent hypoglycemia.
Boyle, P. J., Nagy, R. J., O'Connor, A. M., Kempers, S. F., Yeo, R. A., & Qualls, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9352 · Cited by 208
Magistretti, P. J., Sorg, O., Yu, N., Martin, J.-L., & Pellerin, L. (1994) · Developmental Neuroscience · doi:10.1159/000111349 · Cited by 205 · cited 1×
“This supports the postulation that glial-derived lactate is a significant source of fuel for neurons under stimulated conditions (Dringen et al., 1993; Magistretti et al., 1993; Alves et al., 1995; Griffin et al., 1999).”
BackgroundGERICH, J. E., MOKAN, M., VENEMAN, T., KORYTKOWSKI, M., & MITRAKOU, A. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-4-356 · Cited by 188
Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans
Davis, S. N., Shavers, C., Mosqueda-Garcia, R., & Costa, F. (1997) · Diabetes · doi:10.2337/diab.46.8.1328 · Cited by 183
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Glucose metabolism in fish: a review
Polakof, S., Panserat, S., Soengas, J. L., & Moon, T. W. (2012) · Journal of Comparative Physiology B · doi:10.1007/s00360-012-0658-7 · Cited by 906
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Astrocyte glycogen and brain energy metabolism
Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626
Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587
Some insights into energy metabolism for osmoregulation in fish
Tseng, Y.-C., & Hwang, P.-P. (2008) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.04.009 · Cited by 470
Metadata
- Authors
- Choi, I., Seaquist, E. R., & Gruetter, R.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2003-02-19
- Volume
- 72
- Issue
- 1
- Pages
- 25-32
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2124022771
- Cited by
- 197
- References
- 9
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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