Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss

Doan, Vivian; Kleindienst, Amber M.; McMahon, Eileen J.; Long, Brian R.; Matsushima, Glenn K.; Taylor, Lorelei C.

doi:10.1002/jnr.23174

Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss

Cuprizone intoxication is one of several animal models used to study demyelination and remyelination. Early treatment protocols exposed mice to cuprizone for 6 weeks to induce demyelination; however, more recent reports have varied exposure times from 4 to 5 weeks. The goal of this study was to d…