Sex differences in hippocampal function
Abstract
Sex differences in the function of the hippocampus have been observed in numerous mammalian species. However, the magnitude, extent, and specificity of these differences are unclear because they can depend on factors including age, methodology, and environment. This Review will discuss seminal studies examining sex differences in hippocampal memory, neuronal morphology, synaptic plasticity, and cell signaling in humans and rodents. We also describe possible organizational and activational effects of sex steroid hormones during early development, puberty, and adulthood that may lead to sex differences observed in the hippocampus. We conclude by discussing the implications of sex differences in hippocampal function for mental health. © 2016 Wiley Periodicals, Inc.
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Rodents show sex differences in baseline performance on spatial learning tasks such as the Morris water maze and radial arm maze.
“Similarly, rodents show sex differences in baseline performance on spatial learning tasks such as the Morris water maze and radial arm maze. 108”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [108]
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References 284 · Cited by 156
- Authors
- Koss, W. A., & Frick, K. M.
- Affiliations
- University of Wisconsin–Milwaukee (US)
- Corresponding author
- Frick, Karyn M.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2016-11-07
- Volume
- 95
- Issue
- 1-2
- Pages
- 539-562
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2555625955
- Cited by
- 156
- References
- 284
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 28 · 2022: 15 · 2021: 24 · 2020: 22 · 2019: 21 · 2018: 12 · 2017: 10
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- sex differences, hippocampus, hippocampal-dependent memory, neuronal morphology, synaptic plasticity, signal transduction, sex hormones, organizational effects, activational effects, puberty, brain development, mental health
- MeSH terms
- Animals, Female, Hippocampus, Humans, Male, Memory, Neuronal Plasticity, Sex Characteristics
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