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Cited by 74Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchIon Transport and Channel Regulation

Astrocytes and Glutamine Synthetase in Epileptogenesis

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Eid, Tore, Lee, Tih‐Shih W., Patrylo, Peter, Zaveri, Hitten P.·2019·Journal of Neuroscience Research
DOI 10.1002/jnr.24267PMC PMC6338538
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Abstract

The cellular, molecular, and metabolic mechanisms that underlie the development of mesial temporal lobe epilepsy are incompletely understood. Here we review the role of astrocytes in epilepsy development (a.k.a. epileptogenesis), particularly astrocyte pathologies related to: aquaporin 4, the inwardly rectifying potassium channel Kir4.1, monocarboxylate transporters MCT1 and MCT2, excitatory amino acid transporters EAAT1 and EAAT2, and glutamine synthetase. We propose that inhibition, dysfunction or loss of astrocytic glutamine synthetase is an important causative factor for some epilepsies, particularly mesial temporal lobe epilepsy and glioblastoma‐associated epilepsy. We postulate that the regulatory mechanisms of glutamine synthetase as well as the downstream effects of glutamine synthetase dysfunction, represent attractive, new targets for antiepileptogenic interventions. Currently, no antiepileptogenic therapies are available for human use. The discovery of such interventions is important as it will fundamentally change the way we approach epilepsy by preventing the disease from ever becoming manifest after an epileptogenic insult to the brain.

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Cited by

Sorted by citations

Authors
Eid, T., Lee, T. W., Patrylo, P., & Zaveri, H. P.
Affiliations
  • University of Oslo (NO)
  • Yale University (US)
  • SIU Medicine (US)
Corresponding author
Eid, Tore
ORCID
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2018-07-18
Volume
97
Issue
11
Pages
1345-1362
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
DOI
10.1002/jnr.24267
PMC
PMC6338538
OpenAlex
W2883241721
Cited by
74
References
4
Citations by year
2026: 6 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 5 · 2018: 1
FWCI
0.91
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Center for Advancing Translational Sciences (NS058674, NS070824, TR000142)
  • National Institute of Neurological Disorders and Stroke
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
astrocytes, glutamine synthetase, epileptogenesis, mesial temporal lobe epilepsy, aquaporin-4, Kir4.1, monocarboxylate transporters, glutamate transporters, astrocyte metabolism, antiepileptogenic therapy
MeSH terms
Animals, Astrocytes, Brain, Epilepsy, Temporal Lobe, Glutamate-Ammonia Ligase, Humans

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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