The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression of bcl‐2 inhibits necrotic neural cell death
Abstract
Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto‐oncogene bcl‐2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl‐2 inhibits the necrosis of neural cells induced by glutathione depletion. This finding demonstrates that bcl‐2 does not inhibit the cellular death program directly; rather, bcl‐2 modulates a cellular process that leads to apoptosis under some conditions but necrosis under others. © 1995 Wiley‐Liss, Inc.
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Cites
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Crosstalk between apoptosis.; necrosis and autophagy
Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366
“Moreover, overexpression of BCL-2 was also found suf fi cient to prevent the necrotic death of neuronal [70] and non-neuronal cells [71].”
BackgroundMitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Caspase-independent programmed cell death with necrotic morphology
Kitanaka, C., & Kuchino, Y. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400526 · Cited by 375
Matsuyama, S., Xu, Q., Velours, J., & Reed, J. C. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80033-7 · Cited by 270
Metadata
- Authors
- Kane, D. J., Örd, T., Anton, R., & Bredesen, D. E.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 40
- Issue
- 2
- Pages
- 269-275
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2144074374
- Cited by
- 212
- References
- 1
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kane, D. J., Örd, T., Anton, R., & Bredesen, D. E. (1995). Expression of bcl‐2 inhibits necrotic neural cell death. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.490400216
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
