Distinct frequency dependent effects of whole-body vibration on non-fractured bone and fracture healing in mice
Open accessAbstract
Low-magnitude high-frequency vibration (LMHFV) provokes anabolic effects in non-fractured bone; however, in fracture healing, inconsistent results were reported and optimum vibration conditions remain unidentified. Here, we investigated frequency dependent effects of LMHFV on fracture healing. Twelve-week-old, female C57BL/6 mice received a femur osteotomy stabilized using an external fixator. The mice received whole-body vibrations (20 min/day) with 0.3g peak-to-peak acceleration and a frequency of either 35 or 45 Hz. After 10 and 21 days, the osteotomized femurs and intact bones (contra-lateral femurs, lumbar spine) were evaluated using bending-testing, µ-computed tomography, and histomorphometry. In non-fractured trabecular bone, vibration with 35 Hz significantly increased the relative amount of bone (+28%) and the trabecular number (+29%), whereas cortical bone was not influenced. LMHFV with 45 Hz failed to provoke anabolic effects in trabecular or cortical bone. Fracture healing was not significantly influenced by whole-body vibration with 35 Hz, whereas 45 Hz significantly reduced bone formation (-64%) and flexural rigidity (-34%) of the callus. Although the exact mechanisms remain open, our results suggest that small vibration setting changes could considerably influence LMHFV effects on bone formation in remodeling and repair, and even disrupt fracture healing, implicating caution when treating patients with impaired fracture healing.
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In mice, a vibration frequency of 35 Hz did not affect fracture healing, whereas 45 Hz significantly reduced bone formation and flexural callus rigidity.
“In their study involving mice, a frequency of 35 Hz did not affect fracture healing, whereas a frequency of 45 Hz significantly reduced bone formation and flexural callus rigidity.”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [35]
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References 30 · Cited by 59
Research works printed but not linked: 1
- WEHRLE ET AL. JOURNAL OF ORTHOPAEDIC RESEARCH AUGUST 2014 1554527x, 2014, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/jor.22629 by Readcube (Labtiva Inc.), Wiley Online Library on [25/08/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License using an adjustable external fixator. J Orthop Res 28:1456- 1462. · DOI
- Authors
- Wehrle, E., Wehner, T., Heilmann, A., Bindl, R., Claes, L., Jakob, F., Amling, M., & Ignatius, A.
- Affiliations
- Universität Ulm (DE)
- University of Würzburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Ignatius, Anita
- Venue
- Journal of Orthopaedic Research®
- Publisher
- Wiley
- Published
- 2014-04-14
- Volume
- 32
- Issue
- 8
- Pages
- 1006-1013
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2131026912
- Cited by
- 59
- References
- 30
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 2
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Research Foundation (FOR793, IG18/7-2, SCHI 504/5-2)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Effects of Vibration on Health
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- whole-body vibration, low-magnitude high-frequency vibration, fracture healing, vibration frequency, trabecular bone, cortical bone, bone formation, callus, femoral osteotomy, bone remodeling, bending stiffness
- MeSH terms
- Animals, Biomechanical Phenomena, Female, Mice, Inbred C57BL, Osteogenesis, Vibration, Fracture Healing, Mice, X-Ray Microtomography
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