PAMPA—critical factors for better predictions of absorption

Avdeef, Alex, Bendels, Stefanie, Di, L.i., Faller, Bernard, Kansy, Manfred, Sugano, Kiyohiko, Yamauchi, Yukinori·2007·Journal of Pharmaceutical Sciences
DOI 10.1002/jps.21068

Cited by (252)

Items 201–252 of 252

  1. Preliminary in vitro permeability, cytotoxicity and cardiotoxicity evaluation of triazole-quinuclidine T6
    Kuntarat Arunrungvichian, Putthiporn Khongkaew, Sununta Panyasang, Jiradanai Sarasamkan · 2018 · Pharmaceutical Sciences Asia
  2. Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations
    Angela De Simone, Lara Davani, Serena Montanari, Vander Tumiatti, S. Avanessian, F. Testi, Vincenza Andrisano · 2021 · Frontiers in Chemistry
  3. Use of DMPC and DSPC lipids for verapamil and naproxen permeability studies by PAMPA
    María Javiera Álvarez-Figueroa, B. C. Contreras-Garrido, Marco Soto‐Arriaza · 2014 · Drug Development and Industrial Pharmacy
  4. Validation of Mechanistic Models
    Kiyohiko Sugano · 2012
  5. Automated Drug Screening for ADMET Properties
    Melvin Reichman, Helen Gill · 2010 · Pharmaceutical Sciences Encyclopedia
  6. ADMETInVitroProfiling – Utility and Applications in Lead Discovery
    Edward H. Kerns, Xun Zhang, Li Di · 2021 · Burger's Medicinal Chemistry and Drug Discovery
  7. Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity
    Valeria Poggetti, Elisa Angeloni, Lorenzo Germelli, Benito Natale, Muhammad Salman Waqas, Giuliana Sarno, Andrea Angeli, Simona Daniele, Silvia Salerno, Elisabetta Barresi et al. · 2024 · ACS Chemical Neuroscience
  8. Determination of Permeability and Transbilayer Diffusion Coefficient across Lipid Bilayers of Liposomes by Using Capillary Electrophoresis with Moment Analysis Theory
    Kanji Miyabe, Shunta Inaba · 2025 · Industrial & Engineering Chemistry Research
  9. Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease
    Thaís Cristina Ferreira dos Santos, Ramon B. da Silva, Irene Layane de Sousa, Fabrício Fredo Naciuk, Letícia Marchese, Amanda Gonçalves Eufrásio, Ángel Lobo-Rojas, Renan Marcel Giampauli, Valéria Barbosa de Souza, André Almeida Schenka et al. · 2025 · Frontiers in Pharmacology
  10. Positive modulators of N -methyl- d -aspartate receptor: structure–activity relationship study on steroidal C-17 and C-20 oxime ethers
    Santosh Kumar Adla, Barbora Hrčka Krausová, Bohdan Kysilov, Karel Kudláček, Radko Souček, Miloš Buděšı́nský, Jan Voldřich, Ladislav Vyklický, Eva Kudová · 2026 · RSC Advances
  11. Predicting in vivo performance of piroxicam and apalutamide drug nanocrystals from in vitro flux measurements combined with in silico modelling
    Samuel J. Lee, Shuddhodana, Daniel Bowdery, Aslıhan Arslan, Oksana Tsinman, Edward Hæggström, Bálint Sinkó, Tatiana Danilova · 2026 · International Journal of Pharmaceutics
  12. Effect of Drug–Polymer Interaction on Solid-State Stability and In Vitro Drug Flux of Amorphous Solid Dispersions
    N. S. Krishna Kumar, Corinne Jankovsky, Ewa Zimny, Naveen K. Thakral, Raj Suryanarayanan · 2026 · Molecular Pharmaceutics
  13. An Up-to-Date Look at In Vitro Models of Nose-to-Brain Drug Delivery
    Cansel Köse Özkan, Özgür Eşi̇m, Ayhan Savaşer · 2022 · Springer eBooks
  14. Equilibrium and Nonequilibrium Methods for Free-Energy Calculations With Molecular Dynamics
    Christophe J. Chipot, Paraskevi Gkeka, Tony Lelièvre A, Gabriel Stoltz · 2023 · Elsevier eBooks
  15. 5,5- and 5,6-Membered Spirocyclic Indolinone Hit-Finding Libraries
    Peter J. Meier, Nicole Battaglia, Peter Ertl, Bernard Pirard · 2019 · ACS Combinatorial Science
  16. Workshop Report: USP Workshop on Exploring the Science of Drug Absorption
    Marilyn N. Martinez, Sid Bhoopathy, Sara Carlert, Murat Cirit, Raafat M. Fahmy, Talia R. Flanagan, Ben Forbes, Masoud Jamei, Mansoor A. Khan, Viera Lukáčová et al. · 2019 · Dissolution Technologies
  17. ADMET In VitroProfiling: Utility and Applications in Lead Discovery
    Edward H. Kerns, Li Di, Guy T. Carter · 2010 · Burger's Medicinal Chemistry and Drug Discovery
  18. Oral Site‐Directed Drug Delivery and Influence on PK
    Peter Scholes, Vanessa Zann, Wu Lin, Chris Roe, Bret Berner · 2021
  19. Introduction
    Alex Avdeef · 2012
  20. Quantitative in Vitro ADME Assays Using LC–MS as a Part of Early Drug Metabolism Screening
    Walter A. Korfmacher · 2011
  21. Absorption: In Vitro Tests – Non Cell Based
    Markus Kohlmann · 2013 · Springer eBooks
  22. Pharmaceutical research in the early stages of drug discovery—significance and practice
    Takashi Mano · 2009 · Folia Pharmacologica Japonica
  23. Prediction of the pharmacokinetics of clinical candidates in humans from in vitro data.
    Toshito Nakagawa · 2010 · Folia Pharmacologica Japonica
  24. Innovative in vitro method and permeability estimation procedure to predict drug transport across the blood-brain barrier
    Victor Mangas Sanjuan · 2014 · Repository of Digital Objects for Teaching Research and Culture (University of Valencia)
  25. Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication.
    Scott J. Barraza · 2014 · Deep Blue (University of Michigan)
  26. INVESTIGATING NAT PRODUCTS & PHARMACEUTICALS TARGETING INFLAMMATION IN NEURODEGENERATIVE DISEASES
    Johnson, Shelby L. · 2020
  27. Artificial Gut Simulator for Simultaneous Evaluation of Drug Dissolution and Absorption
    Krutika Harish Jain · 2021 · University of Minnesota Digital Conservancy (University of Minnesota)
  28. Permeability
    Chris Roe, Vanessa Zann · 2021
  29. Drug Parameters
    2012
  30. In Brief
    2007 · Nature Reviews Drug Discovery
  31. Design of an innovative nanovehicle to enhance brain permeability of a novel 5-HT6 receptor antagonist
    María Javiera Álvarez-Figueroa, Francisco Nuñez-Navarro, Gonzalo Recabarren‐Gajardo, José Vicente González-Aramúndiz · 2024 · International Journal of Pharmaceutics X
  32. Computer-Aided Design for Cancer-Targeted Peptide Drugs
    Yan Degenhardt, Michael A. Poss, Xin Gao · 2025 · Methods in pharmacology and toxicology
  33. Utilizing Rapid Mass Spectrometry Techniques to Profile Illicit Drugs from Start to Finish
    Ethan M. McBride · 2018
  34. PKPD modeling and in silico models
    Rikard Pehrson, Susanne Winiwarter, Vigneshwari Subramanian, Mickael Mogemark, Filip N. Miljković · 2025 · Elsevier eBooks
  35. Developing Type II F508del-CFTR correctors with a protective effect against respiratory viruses
    Francesca Barbieri, Maria Grazia Martina, Emanuela Pesce, Elena Bianchi, Noemi Cabella, Emmanuele Crespan, Sara Rossi, Sandra Gemma, Giuseppe Campiani, Ciro Milite et al. · 2025 · European Journal of Medicinal Chemistry
  36. Évaluation de la perméabilité cellulaire de formulations médicamenteuses au travers de membranes d’émulsions adhésives biomimétiques
    Vincent Faugeras · 2021
  37. Nanofitine, module de transport actif pour l'administration orale de biomédicaments
    Solene Masloh · 2022
  38. Lipo‐Glc‐1,6‐ P 2 : A Bioprecursor Prodrug for Phosphomannomutase‐2 Congenital Disorder of Glycosylation
    Federica Sodano, Maria Monticelli, Bruno Hay Mele, Barbara Rolando, Loretta Lazzarato, Angela De Simone, Vincenza Andrisano, Debora Paris, Maria Grazia Rimoli, Maria Vittoria Cubellis et al. · 2026 · IUBMB Life
  39. InNMR: Direct In Situ Studies of Transport Phenomena Enabled by an Innovative NMR-Tube Insert
    Amelie Frison, Marit M. Sørensen, Kristoffer Prince, Maksim Mayzel, Finn. L. Aachmann, Gøril Eide Flaten, Philip Rainsford, Johan Isaksson · 2026 · Analytical Chemistry
  40. A Prodrug Approach for Activity‐Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease
    Jimin Lee, Eunseo Hong, Chanju Na, Yan Li, Jun Go, Ju-Eun Kim, Hyun-Hee Seo, Jong‐Min Suh, Jimin Kwak, Young‐Ho Lee et al. · 2026 · Small
  41. Synthesis and Structure−Activity Relationship (SAR) of Hydroxypyridone-3-carboxamides against Orthopoxviruses
    Ajit Dhananjay Jagtap, Ziyue Wang, Sameera Senaweera, Anil Pant, Djamal Brahim Belhaouari, Jacob P. Mahoney, Roshan A. Katekar, Jiashu Xie, Zhilong Yang, Zhengqiang Wang · 2026 · Journal of Medicinal Chemistry
  42. BindingDB Entry 50034121: Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists.
    BindingDB · 2012 · UC San Diego
  43. BindingDB Entry 50010749: Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases.
    BindingDB · 2021 · UC San Diego
  44. BindingDB Entry 50038109: 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.
    BindingDB · 2012 · UC San Diego
  45. BindingDB Entry 50033595: Imidazolopiperazines: hit to lead optimization of new antimalarial agents.
    BindingDB · 2012 · UC San Diego
  46. BindingDB Entry 50042712: Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.
    BindingDB · 2013 · UC San Diego
  47. BindingDB Entry 50043735: Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.
    BindingDB · 2014 · UC San Diego
  48. BindingDB Entry 50030529: Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
    BindingDB · 2010 · UC San Diego
  49. BindingDB Entry 50001144: Selective Inhibitors of Human Neuraminidase 3.
    BindingDB · 2020 · UC San Diego
  50. BindingDB Entry 50040051: Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
    BindingDB · 2013 · UC San Diego
  51. BindingDB Entry 50033565: FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
    BindingDB · 2012 · UC San Diego
  52. BindingDB Entry 50042286: New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
    BindingDB · 2013 · UC San Diego