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Get real in individual participant data (IPD) meta‐analysis: a review of the methodology
Open accessAbstract
Individual participant data (IPD) meta‐analysis is an increasingly used approach for synthesizing and investigating treatment effect estimates. Over the past few years, numerous methods for conducting an IPD meta‐analysis (IPD‐MA) have been proposed, often making different assumptions and modeling choices while addressing a similar research question. We conducted a literature review to provide an overview of methods for performing an IPD‐MA using evidence from clinical trials or non‐randomized studies when investigating treatment efficacy. With this review, we aim to assist researchers in choosing the appropriate methods and provide recommendations on their implementation when planning and conducting an IPD‐MA. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.
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“more advanced (so-called one-stage) approaches exist to directly combine the IPD with published summary data.67”
From A framework for meta-analysis of prediction model studies with binary and time-to-event outcomes (2019) · cites this paper as [67]
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Metadata
- Authors
- Debray, T. P. A., Moons, K. G. M., van Valkenhoef, G., Efthimiou, O., Hummel, N., Groenwold, R. H. H., Reitsma, J. B., & on behalf of the GetReal methods review group
- Affiliations
- University of Groningen (NL)
- Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen The Netherlands
- University of Ioannina (GR)
- University of Bern (CH)
- University Medical Center Utrecht (NL)
- Corresponding author
- Debray, Thomas P. A.
- ORCID
- Venue
- Research Synthesis Methods
- Publisher
- Wiley
- Published
- 2015-08-19
- Volume
- 6
- Issue
- 4
- Pages
- 293-309
- ISSN
- 1759-2879 (ISSN-L)
- 1759-2887
- PMC
- PMC5042043
- OpenAlex
- W1841651683
- Cited by
- 348
- References
- 121
- Citations by year
- 2026: 28 · 2025: 28 · 2024: 24 · 2023: 36 · 2022: 45 · 2021: 47 · 2020: 35 · 2019: 40 · 2018: 33 · 2017: 16 · 2016: 13 · 2015: 2
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Research Synthesis Methods (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- BORIS (University Library Bern) (submittedVersion, cc-by-nc-nd)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Open Access CRIS of the University of Bern
- Funders
- Innovative Medicines Initiative Joint Undertaking (115546)
- European Union's Seventh Framework Programme (FP7/20072013)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Keywords
- individual patient data meta-analysis, treatment effect estimation, clinical trials, non-randomized studies, methodological assumptions
- MeSH terms
- Data Interpretation, Statistical, Humans, Software, Meta-Analysis as Topic, Models, Statistical, Linear Models, Proportional Hazards Models, Randomized Controlled Trials as Topic, Treatment Outcome
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