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Fundamental and practical aspects of ultrahigh pressure liquid chromatography for fast separations
Abstract
The ongoing development of HPLC has been focused on increasing the speed and efficiency of separations over the past decade. The advances in separation speed have been primarily related to the development of column technology and instrumentation. Relatively short columns packed with sub‐2 μm particles provide high‐speed separations while maintaining or increasing resolution. Ultrahigh pressure pump systems have been developed to overcome the high‐pressure drop generated by such sub‐2 μm packings. In this review, fundamental and practical aspects of ultrahigh pressure or ultrahigh performance liquid chromatography (U‐HPLC) are discussed. Applications of fast U‐HPLC separations are also presented.
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Cited by
Greening analytical chromatography
Welch, C. J., Wu, N., Biba, M., Hartman, R., Brkovic, T., Gong, X., Helmy, R., Schafer, W., Cuff, J., & Pirzada, Z. (2010) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2010.03.008 · Cited by 369
Self-citationPatel, D. P., Nair, S., Suhagia, B. N., & Patel, B. M. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.09.005 · Cited by 15
Metadata
- Authors
- Wu, N., & Clausen, A. M.
- Venue
- Journal of Separation Science
- Publisher
- Wiley
- Published
- 2007-05
- Volume
- 30
- Issue
- 8
- Pages
- 1167-1182
- ISSN
- 1615-9306 (ISSN-L)
- 1615-9314
- OpenAlex
- W2164036543
- Cited by
- 177
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, N., & Clausen, A. M. (2007). Fundamental and practical aspects of ultrahigh pressure liquid chromatography for fast separations. Journal of Separation Science. https://doi.org/10.1002/jssc.200700026
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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