CoChat
Sign Up
Cited by 147Sinusitis and nasal conditionsSleep and related disordersObstructive Sleep Apnea Research

Sleep quality and disease severity in patients with chronic rhinosinusitis

Open access
Alt, Jeremiah A., Smith, Timothy L., Mace, Jess C., Soler, Zachary M.·2013·The Laryngoscope
DOI 10.1002/lary.24040PMC PMC3740761
Open this paper in CoChat — free account

Abstract

Objectives/Hypothesis: To evaluate sleep quality in patients with chronic rhinosinusitis (CRS) using a validated outcome measure and to compare measures of CRS disease severity with sleep dysfunction. Study Design: Cross‐sectional evaluation of a multi‐center cohort. Methods: According to the 2007 Adult Sinusitis Guidelines, patients with CRS were prospectively enrolled from four academic, tertiary care centers across North America. Each subject completed the Pittsburgh Sleep Quality Index (PSQI) instrument, in addition to CRS‐specific measures of quality‐of‐life (QOL), endoscopy, computed tomography (CT), and olfaction. Patient demographics, comorbid conditions, and clinical measures of disease severity were compared between patients with “good” (PSQI; ≤5) and “poor” (PSQI; > 5) sleep quality. Results: Patients (n = 268) reported a mean PSQI score of 9.4 (range: 0–21). Seventy‐five percent of patients reported PSQI scores above the traditional cutoff, indicating poor sleep quality. Patients with poor sleep quality were found to have significantly worse QOL scores on both the Rhinosinusitis Disability Index (P < 0.001) and 22‐item Sinonasal Outcome Test (P < 0.001). No significant differences in average endoscopy, CT, or olfactory function scores were found between patients with good or poor sleep quality. Tobacco smokers reported worse average PSQI total scores compared to nonsmokers (P = 0.030). Patients reporting poor sleep were more likely to have a history of depression, even after controlling for gender (P = 0.020). Conclusion: The majority of patients with CRS have a poor quality of sleep, as measured by the PSQI survey. Poor sleep quality is significantly associated with CRS‐specific QOL, gender, comorbid depression, and tobacco use, but not CT score or endoscopy grade. Level of Evidence: 2b. Laryngoscope, 123:2364–2370, 2013

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/lary.24040

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 55 · Cited by 147

Research works printed but not linked: 44

  1. [1]Serrano E Neukirch F Pribil C Nasal polyposis in France: impact on sleep and quality of life J Laryngol Otol 2005 119 7 543 549 16175980
  2. [3]Buysse DJ Reynolds CF 3rd Monk TH Berman SR Kupfer DJ The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research Psychiatry Res 1989 28 2 193 213 2748771
  3. [4]Pieh C Geisler P Hajak G Pain and sleep disorders MMW Fortschr Med 2012 154 15 61 63 22997943
  4. [6]Otto BA Wenzel SE The role of cytokines in chronic rhinosinusitis with nasal polyps Curr Opin Otolaryngol Head Neck Surg 2008 16 3 270 274 18475084
  5. [7]Pleis JR Ward BW Lucas JW Summary health statistics for U.S. adults: National health interview survey. 2009 Vital Health Stat 10 2010 249 1 207 21905346
  6. [8]Rosenfeld RM Andres D Bhattacharyya N Clinical practice guidelines: adult sinusitis Otolaryngol Head Neck Surg 2007 137 S1 S31 17761281
  7. [9]Benninger MS Senior BA The development of the rhinosinusitis disability index Arch Otolaryngol Head Neck Surg 1997 123 1175 1179 9366696
  8. [10]Hopkins C Gillett S Slack R Psychometric validity of the 22-item Sinonasal Outcome Test Clin Otolaryngol 2009 34 5 447 454 19793277
  9. [11]Lund VJ Mackay IS Staging in rhinosinusitis Rhinology 1993 31 4 183 184 8140385
  10. [12]Lund VJ Kennedy DW Staging in rhinosinusitis Otolaryngol Head Neck Surg 1997 117 3 Pt 2 S35 S40 9334786
  11. [14]Eddy M Walbroehl GS Insomnia Am Fam Physician 1999 59 7 1911 1916 1918 10208709
  12. [15]Ulus Y Akyol Y Tander B Sleep quality in fibromyalgia and rheumatoid arthritis: associations with pain, fatigue, depression, and disease activity Clin Exp Rheumatol 2011 29 Suppl 69 6 S92 S96 22243555
  13. [16]Omachi TA Measures of sleep in rheumatologic diseases: Epworth Sleepiness Scale (ESS), Functional Outcome of Sleep Questionnaire (FOSQ), Insomnia Severity Index (ISI), and Pittsburgh Sleep Quality Index (PSQI) Arthritis Care Res 2011 63 Suppl 11 S287 S296 PMC3711174 22588751
  14. [17]Wells GA Li T Kirwan JR Assessing quality of sleep in patients with rheumatoid arthritis J Rheumatol 2009 36 9 2077 2086 19738217
  15. [18]Batmaz I Sariyildiz MA Dilek B Sleep quality and associated factors in ankylosing spondylitis: relationship with disease parameters, psychological status and quality of life Rheumatol Int In press. 22940709
  16. [19]De Lapiscina EH Aguirre ME Blanco TA Pascual IJ Myasthenia gravis: sleep quality, quality of life, and disease severity Muscle Nerve 2012 46 2 174 180 22806365
  17. [20]Merlino G Fratticci L Lenchig C Prevalence of 'poor sleep' among patients with multiple sclerosis: an independent predictor of mental and physical status Sleep Med 2009 10 1 26 34 18207453
  18. [21]Jankelowitz L Reid KJ Wolfe L Cystic fibrosis patients have poor sleep quality despite normal sleep latency and efficiency Chest 2005 127 5 1593 1599 15888833
  19. [22]Milross MA Piper AJ Norman M Subjective sleep quality in cystic fibrosis Sleep Med 2002 3 3 205 212 14592209
  20. [23]Brandsted R Sindwani R Impact of depression on disease-specific symptoms and quality of life in patients with chronic rhinosinusitis Am J Rhinol 2007 21 1 50 54 17283561
  21. [24]Litvack JR Mace J Smith TL Role of depression in outcomes of endoscopic sinus surgery Otolaryngol Head Neck Surg 2011 144 3 446 451 21493211 PMC3086513
  22. [25]Mace J Michael YL Carlson NE Litvack JR Smith TL Effects of depression on quality of life improvement after endoscopic sinus surgery Laryngoscope 2008 118 3 528 534 18043488
  23. [27]Okun ML Levine MD Houck P Perkins KA Marcus MD Subjective sleep disturbance during a smoking cessation program: associations with relapse Addict Behav 2011 36 8 861 864 21482029 PMC3588159
  24. [28]Zhang L Samet J Caffo B Punjabi NM Cigarette smoking and nocturnal sleep architecture Am J Epidemiol 2006 164 6 529 537 16829553
  25. [29]Jaehne A Loessl B Barkai Z Riemann D Hornyak M Effects of nicotine on sleep during consumption, withdrawal and replacement therapy Sleep Med Rev 2009 13 5 363 377 19345124
  26. [30]Colrain IM Trinder J Swan GE The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations Nicotine Tob Res 2004 6 6 913 925 15801567
  27. [31]Willes SR Fitzgerald TK Permutt T Proud D Haley NJ Bascom R Acute respiratory response to prolonged, moderate levels of sidestream tobacco smoke J Toxicol Environ Health A 1998 53 3 193 209 9482351
  28. [32]Bloom BJ Owens JA McGuinn M Nobile C Schaeffer L Alario AJ Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritis J Rheumatol 2002 29 1 169 173 11824956
  29. [33]Redeker NS Hilkert R Sleep and quality of life in stable heart failure J Card Fail 2005 11 9 700 704 16360966
  30. [34]Aydin O Keskin G Ustundag E Iseri M Ozkarakas H Choanal polyps: an evaluation of 53 cases Am J Rhinol 2007 21 2 164 168 17424872
  31. [35]Tosun F Kemikli K Yetkin S Ozgen F Durmaz A Gerek M Impact of endoscopic sinus surgery on sleep quality in patients with chronic nasal obstruction due to nasal polyposis J Craniofac Surg 2009 20 2 446 449 19276823
  32. [36]Krueger JM Obal F Jr Fang J Why we sleep: a theoretical view of sleep function Sleep Med Rev 1999 3 2 119 129 15310481
  33. [37]Alt JA Bohnet S Taishi P Influenza virus-induced glucocorticoid and hypothalamic and lung cytokine mRNA responses in dwarf lit/lit mice Brain Behav Immun 2007 21 1 60 67 15951155
  34. [38]Thomas KS Motivala S Olmstead R Irwin MR Sleep depth and fatigue: role of cellular inflammatory activation Brain Behav Immun 2011 25 1 53 58 20656013 PMC2991567
  35. [39]Omdal R Gunnarsson R The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis-a pilot study Rheumatol Int 2005 25 6 481 484 15071755
  36. [40]Illi J Miaskowski C Cooper B Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression Cytokine 2012 58 3 437 447 22450224 PMC3340525
  37. [41]Anisman H Merali Z Cytokines, stress and depressive illness: brain-immune interactions Ann Med 2003 35 1 2 11 12693607
  38. [42]Baune BT Ponath G Rothermundt M Riess O Funke H Berger K Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study Psychoneuroendocrinology 2008 33 1 68 76 17988804
  39. [43]Palin K Bluthe RM Verrier D Tridon V Dantzer R Lestage J Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guerin in the rat hippocampus Brain Behav Immun 2004 18 3 223 230 15050649
  40. [47]Carpenter JS Andrykowski MA Psychometric evaluation of the Pittsburgh Sleep Quality Index J Psychosom Res 1998 45 1 5 13 9720850
  41. [48]Spira AP Beaudreau SA Stone KL Reliability and validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older men J Gerontol A Biol Sci Med Sci 67 4 433 439 21934125 PMC3309871
  42. [49]Buysse DJ Hall ML Strollo PJ Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical/polysomnographic measures in a community sample J Clin Sleep Med 2008 4 6 563 571 19110886 PMC2603534
  43. [50]Backhaus J Junghanns K Broocks A Riemann D Hohagen F Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia J Psychosom Res 2002 53 3 737 740 12217446
  44. [51]Sangal RB Sangal JM Rating scales for inattention and sleepiness are correlated in adults with symptoms of sleep disordered breathing syndrome, but not in adults with symptoms of attention-deficit/hyperactivity disorder Sleep Med 2004 5 2 133 135 15033132

Authors
Alt, J. A., Smith, T. L., Mace, J. C., & Soler, Z. M.
Affiliations
  • Oregon Health & Science University (US)
  • Medical University of South Carolina (US)
Corresponding author
Smith, Timothy L.
ORCID
Venue
The Laryngoscope
Publisher
Wiley
Published
2013-08-05
Volume
123
Issue
10
Pages
2364-2370
ISSN
  • 0023-852X (ISSN-L)
  • 1531-4995
DOI
10.1002/lary.24040
PMC
PMC3740761
OpenAlex
W2164533702
Cited by
147
References
55
Citations by year
2026: 3 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 19 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 7 · 2017: 12 · 2016: 16 · 2015: 15 · 2014: 7 · 2013: 2
FWCI
12.10
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Laryngoscope (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Medical University of South Carolina
  • University of Calgary
  • National Institute on Deafness and Other Communication Disorders (R01DC005805)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Keywords
chronic rhinosinusitis, sleep quality, Pittsburgh Sleep Quality Index, disease severity, quality of life, Rhinosinusitis Disability Index, depression, tobacco use, olfactory function, endoscopic grading
MeSH terms
Adult, Aged, Aged, 80 and over, Chronic Disease, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Rhinitis, Risk Factors, Severity of Illness Index, Sinusitis, Sleep, Sleep Wake Disorders, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review