The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
RETRACTED: Effects of low‐level laser therapy (LLLT) on the nuclear factor (NF)‐κB signaling pathway in traumatized muscle
Abstract
Background and Objective: To investigate the effects of low‐level laser therapy (LLLT) on nuclear factor kappa B (NF‐κB) activation and inducible nitric oxide synthase (iNOS) expression in an experimental model of muscle trauma. Study Design/Materials and Methods: Injury to the gastrocnemius muscle in the rat was produced by a single impact blunt trauma. A low‐level galium arsenide (Ga–As) laser (904 nm, 45 mW, and 5 J/cm 2 ) was applied for 35 seconds duration, continuously. Results: Histological abnormalities with increase in collagen concentration, and oxidative stress were observed after trauma. This was accompanied by activation of NF‐κB and upregulation of iNOS expression, whereas protein concentration of IκBα decreased. These effects were blocked by LLLT. Conclusion: LLLT reduced the inflammatory response induced by trauma and was able to block the effects of reactive oxygen species (ROS) release and the activation of NF‐κB. The associated reduction of iNOS overexpression and collagen production suggest that the NF‐κB pathway may be a signaling route involved in the pathogenesis of muscle trauma. Lasers Surg. Med. © 2006 Wiley‐Liss, Inc.
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Cites
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212
Nitric oxide, an autocrine regulator of wound fibroblast synthetic function
Schäffer, M. R., Efron, P. A., Thornton, F. J., Klingel, K., Gross, S. S., & Barbul, A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2375 · Cited by 260 · cited 1×
“decreases collagen synthesis in rats [50], and dermal fibroblasts from iNOS knock-out mice synthesized less collagen and proliferated more slowly [51].”
Potential Therapeutic Effect of Antioxidant Therapy in Shock and Inflammation
Cuzzocrea, S., Thiemermann, C., & Salvemini, D. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365396 · Cited by 129
Cited by
Molecular mechanisms of cell proliferation induced by low power laser irradiation
Gao, X., & Xing, D. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-4 · Cited by 507
Bjordal, J. M., Bensadoun, R.-J., Tunèr, J., Frigo, L., Gjerde, K., & Lopes-Martins, R. A. (2011) · Supportive Care in Cancer · doi:10.1007/s00520-011-1202-0 · Cited by 272
Metadata
- Authors
- Rizzi, C. F., Mauriz, J. L., Freitas Corrêa, D. S., Moreira, A. J., Zettler, C. G., Filippin, L. I., Marroni, N. P., & González‐Gallego, J.
- Venue
- Lasers in Surgery and Medicine
- Publisher
- Wiley
- Published
- 2006-06-23
- Volume
- 38
- Issue
- 7
- Pages
- 704-713
- ISSN
- 0196-8092 (ISSN-L)
- 1096-9101
- OpenAlex
- W2064443786
- Cited by
- 237
- References
- 3
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- CoChat. (2026). Citation check: RETRACTED: Effects of low‐level laser therapy (LLLT) on the nuclear factor (NF)‐κB signaling pathway in traumatized muscle. https://app.cochat.ai/papers/10.1002/lsm.20371
- The paper
- Rizzi, C. F., Mauriz, J. L., Freitas Corrêa, D. S., Moreira, A. J., Zettler, C. G., Filippin, L. I., Marroni, N. P., & González‐Gallego, J. (2006). RETRACTED: Effects of low‐level laser therapy (LLLT) on the nuclear factor (NF)‐κB signaling pathway in traumatized muscle. Lasers in Surgery and Medicine. https://doi.org/10.1002/lsm.20371
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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