The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gold Nanoparticles as a Versatile Platform for Optimizing Physicochemical Parameters for Targeted Drug Delivery
Abstract
Summary:The development of targeted vehicles for systemic drug delivery relies on optimizing both the cell‐targeting ligand and the physicochemical characteristics of the nanoparticle carrier. A versatile platform based on modification of gold nanoparticles with thiolated polymers is presented in which design parameters can be varied independently and systematically. Nanoparticle formulations of varying particle size, surface charge, surface hydrophilicity, and galactose ligand density were prepared by conjugation of PEG‐thiol and galactose‐PEG‐thiol to gold colloids. This platform was applied to screen for nanoparticle formulations that demonstrate hepatocyte‐targeted delivery in vivo. Nanoparticle size and the presence of galactose ligands were found to significantly impact the targeting efficiency. Thus, this platform can be readily applied to determine design parameters for targeted drug delivery systems. Modified gold nanoparticles are a suitable model for nanoparticle‐based gene carriers. magnified imageModified gold nanoparticles are a suitable model for nanoparticle‐based gene carriers.
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Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178
Polymer vesicles in vivo: correlations with PEG molecular weight
Photos, P. J., Bacakova, L., Discher, B., Bates, F. S., & Discher, D. E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00201-3 · Cited by 527
Cited by
Gold nanoparticles in delivery applications☆
GHOSH, P., HAN, G., DE, M., KIM, C., & ROTELLO, V (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.016 · Cited by 2,694
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,730
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261
Kupffer cells are central in the removal of nanoparticles from the organism
Sadauskas, E., Wallin, H., Stoltenberg, M., Vogel, U., Doering, P., Larsen, A., & Danscher, G. (2007) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-4-10 · Cited by 607
Gold Nanoparticles in Cancer Treatment
Sztandera, K., Gorzkiewicz, M., & Klajnert-Maculewicz, B. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00810 · Cited by 607
Metadata
- Authors
- Bergen, J. M., von Recum, H. A., Goodman, T. T., Massey, A. P., & Pun, S. H.
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2006-07-03
- Volume
- 6
- Issue
- 7
- Pages
- 506-516
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2104009735
- Cited by
- 225
- References
- 2
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bergen, J. M., von Recum, H. A., Goodman, T. T., Massey, A. P., & Pun, S. H. (2006). Gold Nanoparticles as a Versatile Platform for Optimizing Physicochemical Parameters for Targeted Drug Delivery. Macromolecular Bioscience. https://doi.org/10.1002/mabi.200600075
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