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Cited by 174Nanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersAdvanced Drug Delivery Systems

Physico-chemical strategies to enhance stability and drug retention of polymeric micelles for tumor-targeted drug delivery

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Shi, Yang, Lammers, Twan, Storm, Gert, Hennink, Wim E.·2017·Macromolecular Bioscience
DOI 10.1002/mabi.201600160PMC PMC5410994
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Abstract

Polymeric micelles (PM) have been extensively used for tumor‐targeted delivery of hydrophobic anti‐cancer drugs. The lipophilic core of PM is naturally suitable for loading hydrophobic drugs and the hydrophilic shell endows them with colloidal stability and stealth properties. Decades of research on PM have resulted in tremendous numbers of PM‐forming amphiphilic polymers, and approximately a dozen micellar nanomedicines have entered the clinic. The first generation of PM can be considered solubilizers of hydrophobic drugs, with short circulation times resulting from poor micelle stability and unstable drug entrapment. To more optimally exploit the potential of PM for targeted drug delivery, several physical (e.g., π–π stacking, stereocomplexation, hydrogen bonding, host–guest complexation, and coordination interaction) and chemical (e.g., free radical polymerization, click chemistry, disulfide and hydrazone bonding) strategies have been developed to improve micelle stability and drug retention. In this review, the most promising physico‐chemical approaches to enhance micelle stability and drug retention are described, and how these strategies have resulted in systems with promising therapeutic efficacy in animal models, paving the way for clinical translation, is summarized. image

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  • Additional molecular interactions in the core, such as hydrogen bonding and pi-pi interactions, can strengthen polymer-drug interactions.

    “Additional molecular interactions existing in the core, such as hydrogen bonding and pi-pi interactions, are no less significant as they can strengthen the molecular interactions between the polymer and the drug in the core [28, 39].”

    From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [39]

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Authors
Shi, Y., Lammers, T., Storm, G., & Hennink, W. E.
Affiliations
  • South China University of Technology (CN)
  • Utrecht University (NL)
Corresponding author
Hennink, Wim E.
ORCID
Venue
Macromolecular Bioscience
Publisher
Wiley
Published
2016-07-14
Volume
17
Issue
1
ISSN
  • 1616-5187 (ISSN-L)
  • 1616-5195
DOI
10.1002/mabi.201600160
PMC
PMC5410994
OpenAlex
W2461228950
Cited by
174
References
106
Citations by year
2026: 12 · 2025: 18 · 2024: 16 · 2023: 14 · 2022: 17 · 2021: 22 · 2020: 25 · 2019: 17 · 2018: 19 · 2017: 14
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Macromolecular Bioscience (publishedVersion)
  • PubMed (publishedVersion)
  • University of Twente Research Information (publishedVersion, other-oa)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
  • University of Twente Research Information (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
Funders
  • European Research Council (StG‐309495‐NeoNaNo, PoC‐680882‐CONQUEST, StG-309495-NeoNaNo, PoC-680882-CONQUEST)
  • Deutsche Forschungsgemeinschaft (La2937/1‐2, La2937/1-2)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric micelles, anticancer drug delivery, micelle stability, drug retention, hydrophobic anticancer drugs, amphiphilic polymers, π-π stacking, stereocomplexation, hydrogen bonding, host-guest complexation, coordination interactions, click chemistry, disulfide bonds, hydrazone bond, radical polymerization, clinical translation
MeSH terms
Pharmaceutical Preparations, Micelles, Neoplasms, Polymers, Drug Delivery Systems, Chemical Phenomena

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