Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2013–2014
Abstract
This review is the eighth update of the original article published in 1999 on the application of Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo- and poly- saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. © 2018 Wiley Periodicals, Inc. Mass Spec Rev 37:353-491, 2018.
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MALDI has risen to prominence for its exquisite sensitivity, tolerance to impurities, high-throughput capacity, ease of data analysis (given that most ions are singly charged) and simplicity of sample preparation.
“MALDI in particular has risen to prominence for its exquisite sensitivity, tolerance to impurities, high-throughput capacity, ease of data analysis (given that most ions are singly charged) and the simplicity of sample preparation [146].”
From Glycoengineering Chinese hamster ovary cells: a short history (2021) · cites this paper as [146]
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- Authors
- Harvey, D. J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Harvey, David J.
- ORCID
- Harvey, David J.
- Venue
- Mass Spectrometry Reviews
- Publisher
- Wiley
- Published
- 2018-04-17
- Volume
- 37
- Issue
- 4
- Pages
- 353-491
- ISSN
- 0277-7037 (ISSN-L)
- 1098-2787
- OpenAlex
- W2334297213
- Cited by
- 61
- References
- 1,721
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 18 · 2020: 5 · 2019: 8 · 2018: 11 · 2017: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mass Spectrometry Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- MALDI mass spectrometry, carbohydrates, glycoconjugates, MALDI matrix, derivatization, MALDI mass spectrometry imaging, fragmentation, oligosaccharides, polysaccharides, glycoproteins, glycolipids, glycosides, biopharmaceuticals, enzymatic reactions, chemical synthesis
- MeSH terms
- Animals, Bacteria, Biological Products, Carbohydrate Sequence, Fungi, Glycolipids, Glycoproteins, Glycosides, Glycosylation, Humans, Oligosaccharides, Polysaccharides, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Hydrozoa, Carbohydrate Metabolism
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