Activating transcription factor 1 promoted migration and invasion in lung cancer cells through regulating EGFR and MMP‐2
Abstract
Lung cancer is among the most frequently occurring cancers and the leading cause of cancer-related deaths worldwide. Nonsmall cell lung cancer is accountable for 85% to 90% of all lung cancer cases and develops distant metastases with high mortality. In this work, we elucidated the role of activating transcription factor 1 (ATF1) in migration and invasion of lung cancer cells. We found that the migration and invasion were inhibited with ATF1 silencing in lung cancer cells. By contrast, ATF1 overexpression led to promotion in migration and invasion. The alteration in ATF1 expression induced a change in the epidermal growth factor receptor (EGFR) and matrix metalloproteinases (MMP)-2 expression level in the same tendency. Thus, we provided a potential new candidate for therapies against lung cancer, showing the possible mechanism underlying the invasion and migration of lung cancer cells.
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ATF1 is known to influence the expression of matrix metalloproteinases across multiple diseases.
“The transcription factor ATF1 is known to influence the expression of matrix metalloproteinases across multiple diseases30,31.”
From ATF1 and miR-27b-3p drive intervertebral disc degeneration through the PPARG/NF-κB signaling axis (2025) · cites this paper as [30]
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Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer
Li, T., Cao, H., Wu, S., Zhong, P., Ding, J., Wang, J., Wang, F., He, Z., & Huang, G.-L. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03361-3 · Cited by 16 · see citing works
ATF1 and miR-27b-3p drive intervertebral disc degeneration through the PPARG/NF-κB signaling axis
Guo, W., Mu, K., Geng, J.-C., Xing, H.-Y., Dong, Y., Liu, W.-D., Wang, S.-C., Shi, J.-X., Xing, B.-R., Zhao, J.-Y., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08186-6 · Cited by 7 · see citing works
- Authors
- Cui, J., Yin, Z., Liu, G., Chen, X., Gao, X., Lu, H., Li, W., & Lin, D.
- Affiliations
- Suzhou Municipal Hospital (CN)
- Department of Respiratory Medicine, Suzhou Municipal Hospital Suzhou Hospital Affiliated Nanjing Medical University Suzhou Jiangsu China
- Corresponding author
- Lin, Dang
- Venue
- Molecular Carcinogenesis
- Publisher
- Wiley
- Published
- 2019-08-16
- Volume
- 58
- Issue
- 10
- Pages
- 1919-1924
- ISSN
- 0899-1987 (ISSN-L)
- 1098-2744
- OpenAlex
- W2967925028
- Cited by
- 24
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 1
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- lung cancer, non-small cell lung cancer, cell migration, cell invasion, epidermal growth factor receptor, MMP-2, metastasis, gene silencing, therapeutic target
- MeSH terms
- Cell Movement, Female, Humans, Lung Neoplasms, Male, Neoplasm Invasiveness, Proteins, Signal Transduction, Gene Expression Regulation, Neoplastic, Matrix Metalloproteinase 2, Cell Line, Tumor, Cell Proliferation, ErbB Receptors
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