LATS‐regulated nuclear‐cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial–mesenchymal transition

Zhang, Feng; Gao, Jie; Liu, Xudong; Sun, Yaohui; Liu, Long; Hu, Bowen; Wang, Zhihui; Shi, Jihua; Guo, Wenzhi; Zhang, Shuijun

doi:10.1002/mc.23538

LATS‐regulated nuclear‐cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial–mesenchymal transition

Abnormal cholesterol synthesis plays a crucial role in the development of hepatocellular carcinoma (HCC). Sterol regulatory element‐binding protein 2 (SREBP2) is involved in cholesterol synthesis by translocating to the nucleus where it stimulates the transcription of genes encoding enzymes invol…