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Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene
Abstract
To determine whether the c‐Ha‐ras oncogene plays a role in the initiation of mammary carcinogenesis, an immortalized human breast epithelial cell line, MCF‐10A, was transfected with the plasmid vector pHo6T1 containing the T24 Ha‐ras oncogene and the aminoglycoside phosphotransferase gene, which confers resistance to geneticin. Transfected cells exhibited an altered pattern of growth and tridimensional morphology in collagen gel. They also exhibited anchorage‐independent growth and loss of requirement for hormones and epidermal growth factor; in addition, they expressed invasiveness and increased collagenolytic activity in an in vitro system and became tumorigenic in irradiated nude mice, all properties indicative of malignant transformation. Transformed cells contained the mutated c‐Ha‐ras oncogene and expressed the p21 mutated protein. These data indicate that the c‐Ha‐ras oncogene is capable of inducing malignant phenotypes in immortalized human breast epithelial cells.
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Citations
Cited by
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J., & Brugge, J. S. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-785 · Cited by 554
Malignant MCF10CA1 Cell Lines Derived from Premalignant Human Breast Epithelial MCF10AT Cells
Santner, S. J., Dawson, P. J., Tait, L., Soule, H. D., Eliason, J., Mohamed, A. N., Wolman, S. R., Heppner, G. H., & Miller, F. R. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1006461422273 · Cited by 408
Self-citationYamamoto, T., Harada, N., Kano, K., Taya, S.-I., Canaani, E., Matsuura, Y., Mizoguchi, A., Ide, C., & Kaibuchi, K. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.785 · Cited by 314
Nishimura, Y., Itoh, K., Yoshioka, K., Uehata, M., & Himeno, M. (2000) · Cell and Tissue Research · doi:10.1007/s004410000243 · Cited by 22
Metadata
- Authors
- Basolo, F., Elliott, J., Tait, L., Chen, X. Q., Maloney, T., Russo, I. H., Pauley, R., Momiki, S., Caamano, J., Klein‐Szanto, A. J. P., Koszalka, M., & Russo, J.
- Venue
- Molecular Carcinogenesis
- Publisher
- Wiley
- Published
- 1991-01
- Volume
- 4
- Issue
- 1
- Pages
- 25-35
- ISSN
- 0899-1987 (ISSN-L)
- 1098-2744
- OpenAlex
- W2063627291
- Cited by
- 160
- References
- 0
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Basolo, F., Elliott, J., Tait, L., Chen, X. Q., Maloney, T., Russo, I. H., Pauley, R., Momiki, S., Caamano, J., Klein‐Szanto, A. J. P., Koszalka, M., & Russo, J. (1991). Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene. Molecular Carcinogenesis. https://doi.org/10.1002/mc.2940040106
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