Developing a Tool for Remote Digital Assessment of Parkinson's Disease
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Background: The natural fluctuation of motor symptoms of Parkinson's disease ( PD ) makes judgement of any change challenging and the use of clinical scales such as the International Parkinson and Movement Disorder Society ( MDS )‐ UPDRS imperative. Recently developed commodity mobile communication devices, such as smartphones, could possibly be used to assess motor symptoms in PD patients in a convenient way with low cost. We provide the first report on the development and testing of stand‐alone software for mobile devices that could be used to assess both tremor and bradykinesia of PD patients. Methods: We assessed motor symptoms with a custom‐made smartphone application in 14 patients and compared the results with their MDS ‐ UPDRS scores. Results: We found significant correlation between five subscores of MDS ‐ UPDRS (rest tremor, postural tremor, pronation‐supination, leg agility, and finger tapping) and eight parameters of the data collected with the smartphone. Conclusions: These results provide evidence as a proof of principle that smartphones could be a useful tool to objectively assess motor symptoms in PD in clinical and experimental settings.
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Kassavetis and colleagues tested 14 PD participants with the MDS-UPDRS and a custom Android application with active tests, and for all tasks, the extracted sensor feature data significantly correlated with corresponding MDS-UPDRS item scores.
“For example, Kassavetis and colleagues18 tested 14 PD participants (mean disease duration = 3.7 years) with the MDS‐UPDRS25 and a custom Android application with the following active tests: resting, postural and kinetic tremor, pronation‐supination, leg agility, and finger‐tapping. For all tasks, the extracted sensor feature data significantly correlated with corresponding MDS‐UPDRS25 item scores”
From Evaluation of smartphone‐based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial (2018) · cites this paper as [18]
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References 11 · Cited by 69
Research works printed but not linked: 1
- C. Review and Critique; (3) Manuscript Preparation: A. Writ- ing of the First Draft, B. Review and Critique. P.K.: 1B, 1C, 2A, 2B, 2C, 3A
- Authors
- Kassavetis, P., Saifee, T. A., Roussos, G., Drougkas, L., Kojovic, M., Rothwell, J. C., Edwards, M. J., & Bhatia, K. P.
- Affiliations
- Boston University (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Birkbeck, University of London (GB)
- Sobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology Queen Square London United Kingdom
- Corresponding author
- Bhatia, Kailash P.
- ORCID
- Venue
- Movement Disorders Clinical Practice
- Publisher
- Wiley
- Published
- 2015-10-20
- Volume
- 3
- Issue
- 1
- Pages
- 59-64
- ISSN
- 2330-1619 (ISSN-L)
- PMC
- PMC6178716
- OpenAlex
- W2191082636
- Cited by
- 69
- References
- 11
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 4
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Movement Disorders Clinical Practice (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BIROn (Birkbeck, University of London) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Bachmann-Strauss Dystonia and Parkinson Foundation
- Parkinson's UK (G‐1009)
- Dystonia Medical Research Foundation
- International Parkinson and Movement Disorder Society
- Guarantors of Brain
- National Institute for Health Research
- Seventh Framework Programme
- Engineering and Physical Sciences Research Council
- Joint Information Systems Committee
- Tourette Association of America
- Stroke Association
- GlaxoSmithKline
- Ipsen Fund
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- Parkinson's disease, mobile application, remote assessment, motor symptoms, tremor, bradykinesia, MDS-UPDRS, objective assessment, mobile health, resting tremor, postural tremor, finger tapping
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