The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Impact of dopamine transporter SPECT using 123I‐Ioflupane on diagnosis and management of patients with clinically uncertain parkinsonian syndromes
Abstract
Imaging with 123 I‐Ioflupane single‐photon emission computed tomography (SPECT) is a marker of nigrostriatal neuronal integrity, allowing differentiation of parkinsonism with loss of dopaminergic terminals (presynaptic Parkinson syndrome [PS]) from parkinsonism without nigrostriatal degeneration. This study assessed SPECT imaging in 118 patients with clinically uncertain parkinsonian syndromes (CUPS). In 36% of patients with presynaptic PS and 54% with nonpresynaptic PS, imaging results were not consistent with the initial diagnosis. After imaging, diagnosis was changed in 52% of patients. All patients with a final diagnosis of presynaptic PS had an abnormal image, whereas 94% of patients with nonpresynaptic PS had a normal scan. Imaging increased confidence in diagnosis, leading to changes in clinical management in 72% of patients. Consequently, visual assessment of 123 I‐Ioflupane SPECT may have a significant impact on the clinical management of CUPS patients. © 2004 Movement Disorder Society
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Metadata
- Authors
- Catafau, A. M., & Tolosa, E.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2004-04-22
- Volume
- 19
- Issue
- 10
- Pages
- 1175-1182
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2017525257
- Cited by
- 290
- References
- 17
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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