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Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)

Wenning, Gregor K., Tison, Franc̨ois, Seppi, Klaus, Sampaio, Cristina, Diem, Anja, Yekhlef, Farid, Ghorayeb, Imad, Ory, Fabienne, Galitzky, Monique, Scaravilli, Tommaso, Bozi, Maria, Colosimo, Carlo, Gilman, Sid, Shults, Clifford W., Quinn, Niall P., Rascol, Olivier, Poewe, Werner, and the Multiple System Atrophy Study Group·2004·Movement Disorders

Abstract

We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale ‐ UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS‐I (Crohnbach's alpha = 0.84) and UMSARS‐II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS‐I and ‐II items as well as of total UMSARS‐I and ‐II subscores was substantial (k (w) = 0.6–0.8) to excellent (k (w) > 0.8). UMSARS‐II correlated well with UPDRS‐III and ICARS (r s > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients. © 2004 Movement Disorder Society

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Metadata

Authors
Wenning, G. K., Tison, F., Seppi, K., Sampaio, C., Diem, A., Yekhlef, F., Ghorayeb, I., Ory, F., Galitzky, M., Scaravilli, T., Bozi, M., Colosimo, C., Gilman, S., Shults, C. W., Quinn, N. P., Rascol, O., Poewe, W., & and the Multiple System Atrophy Study Group
Venue
Movement Disorders
Publisher
Wiley
Published
2004-10-27
Volume
19
Issue
12
Pages
1391-1402
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
OpenAlex
W2044841974
Cited by
606
References
2
FWCI
7.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). https://app.cochat.ai/papers/10.1002/mds.20255
The paper
Wenning, G. K., Tison, F., Seppi, K., Sampaio, C., Diem, A., Yekhlef, F., Ghorayeb, I., Ory, F., Galitzky, M., Scaravilli, T., Bozi, M., Colosimo, C., Gilman, S., Shults, C. W., Quinn, N. P., Rascol, O., Poewe, W., & and the Multiple System Atrophy Study Group. (2004). Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Movement Disorders. https://doi.org/10.1002/mds.20255

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