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Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

Open access
Moro, Elena, Lozano, Andres M., Pollak, Pierre, Agid, Yves, Rehncrona, Stig, Volkmann, Jens, Kulisevsky, Jaime, Obeso, Jose A., Albanese, Alberto, Hariz, Marwan I., Quinn, Niall P., Speelman, Jans D., Benabid, Alim L., Fraix, Valerie, Mendes, Alexandre, Welter, Marie‐Laure, Houeto, Jean‐Luc, Cornu, Philippe, Dormont, Didier, Tornqvist, Annalena L., Ekberg, Ron, Schnitzler, Alfons, Timmermann, Lars, Wojtecki, Lars, Gironell, Andres, Rodriguez‐Oroz, Maria C., Guridi, Jorge, Bentivoglio, Anna R., Contarino, Maria F., Romito, Luigi, Scerrati, Massimo, Janssens, Marc, Lang, Anthony E.·2010·Movement Disorders

Abstract

We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society

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Authors
Moro, E., Lozano, A. M., Pollak, P., Agid, Y., Rehncrona, S., Volkmann, J., Kulisevsky, J., Obeso, J. A., Albanese, A., Hariz, M. I., Quinn, N. P., Speelman, J. D., Benabid, A. L., Fraix, V., Mendes, A., Welter, M., Houeto, J., Cornu, P., Dormont, D., Tornqvist, A. L., Ekberg, R., Schnitzler, A., Timmermann, L., Wojtecki, L., Gironell, A., Rodriguez‐Oroz, M. C., Guridi, J., Bentivoglio, A. R., Contarino, M. F., Romito, L., Scerrati, M., Janssens, M., & Lang, A. E.
Venue
Movement Disorders
Publisher
Wiley
Published
2010-04-15
Volume
25
Issue
5
Pages
578-586
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
OpenAlex
W2169661540
Cited by
468
References
26
FWCI
25.01
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease. https://app.cochat.ai/papers/10.1002/mds.22735
The paper
Moro, E., Lozano, A. M., Pollak, P., Agid, Y., Rehncrona, S., Volkmann, J., Kulisevsky, J., Obeso, J. A., Albanese, A., Hariz, M. I., Quinn, N. P., Speelman, J. D., Benabid, A. L., Fraix, V., Mendes, A., Welter, M., Houeto, J., Cornu, P., Dormont, D., . . . Lang, A. E. (2010). Long‐term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease. Movement Disorders. https://doi.org/10.1002/mds.22735

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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