Elevated in vivo [18F]‐AV‐1451 uptake in a patient with progressive supranuclear palsy
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Earlier PET investigations have detected alterations in PSP with ligands for tau and for microglial activation.
“Previous positron emission tomography (PET) has indicated changes in PSP using ligands targeting tau8–16 and microglial activation17,18.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [10]
In PSP, higher [18F]AV-1451 binding is found in subcortical rather than cortical regions, consistent with the known distribution of PSP-Richardson's syndrome.
“In PSP, higher [18F]AV-1451 binding has been found in sub-cortical rather than cortical regions (the reverse for AD), consistent with the well-established cortical versus sub-cortical distribution of PSP-Richardson’s syndrome8–10,13,14,16.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [10]
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References 9 · Cited by 49
- Authors
- Hammes, J., Bischof, G. N., Giehl, K., Faber, J., Drzezga, A., Klockgether, T., & van Eimeren, T.
- Affiliations
- University of Cologne (DE)
- Forschungszentrum Jülich (DE)
- University of Bonn (DE)
- Multimodal Neuroimaging Group Department of Nuclear Medicine University of Cologne Cologne Germany
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2016-08
- Volume
- 32
- Issue
- 1
- Pages
- 170-171
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2490117974
- Cited by
- 49
- References
- 9
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 12 · 2017: 13 · 2016: 3
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- 18F-AV-1451, FDG-PET, progressive supranuclear palsy, amyloid imaging, neurodegeneration, brain amyloid
- MeSH terms
- Aged, Basal Ganglia, Carbolines, Humans, Magnetic Resonance Imaging, Male, Supranuclear Palsy, Progressive, Tomography, Emission-Computed, Single-Photon, tau Proteins, Positron-Emission Tomography
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