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Recent progress in the development of coumarin derivatives as potent anti‐HIV agents
Abstract
Numerous plant‐derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure–activity relationship studies of potent anti‐HIV coumarin derivatives. A dicamphanoyl‐khellactone (DCK) analog, which was discovered and developed in our laboratory, and calanolide A are currently in preclinical studies and clinical trials, respectively. © 2003 Wiley Periodicals, Inc. Med Res Rev, 23, No. 3, 322‐345, 2003
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Cited by
Coumarin-Based Small-Molecule Fluorescent Chemosensors
Cao, D., Liu, Z., Verwilst, P., Koo, S., Jangjili, P., Kim, J. S., & Lin, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00145 · Cited by 1,306
Natural products to drugs: natural product-derived compounds in clinical trials
Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,075
Singh, M. S., & Chowdhury, S. (2012) · RSC Advances · doi:10.1039/c2ra01056a · Cited by 506
Plant-derived compounds in clinical trials
Saklani, A., & Kutty, S. K. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.10.010 · Cited by 477
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Medina, F. G., Marrero, J. G., Macías-Alonso, M., González, M. C., Córdova-Guerrero, I., Teissier García, A. G., & Osegueda-Robles, S. (2015) · Natural Product Reports · doi:10.1039/c4np00162a · Cited by 469
Metadata
- Authors
- Yu, D., Suzuki, M., Xie, L., Morris‐Natschke, S. L., & Lee, K.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2003-02-03
- Volume
- 23
- Issue
- 3
- Pages
- 322-345
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2009307924
- Cited by
- 515
- References
- 0
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, D., Suzuki, M., Xie, L., Morris‐Natschke, S. L., & Lee, K. (2003). Recent progress in the development of coumarin derivatives as potent anti‐HIV agents. Medicinal Research Reviews. https://doi.org/10.1002/med.10034
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