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Boronolectins and fluorescent boronolectins: An examination of the detailed chemistry issues important for the design
Abstract
Glycans in the form of glycoproteins or glycolipids play very critical roles in various biological and pathological processes including inflammation, cancer metastasis, immune reactions, embryo development, cell–cell communications and adhesions, blood generation, etc. Proteins (lectins) that can recognize carbohydrates have played very important roles in studying glycobiology. Small molecule mimics of lectins will be very useful in the development of new therapeutics and diagnostics. Along this line, boronic acids have been widely used in the design and synthesis of small organic compounds that mimic the function of lectins. This review examines in detail the factors that are important for the design of boronic acid‐based lectin mimics, boronolectins. © 2005 Wiley Periodicals, Inc.
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Cited by
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Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Glucose Sensing in Supramolecular Chemistry
Sun, X., & James, T. D. (2015) · Chemical Reviews · doi:10.1021/cr500562m · Cited by 386
Metadata
- Authors
- Yan, J., Fang, H., & Wang, B.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2005-07-15
- Volume
- 25
- Issue
- 5
- Pages
- 490-520
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2159863025
- Cited by
- 185
- References
- 0
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yan, J., Fang, H., & Wang, B. (2005). Boronolectins and fluorescent boronolectins: An examination of the detailed chemistry issues important for the design. Medicinal Research Reviews. https://doi.org/10.1002/med.20038
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