The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders

Vidoni, Chiara, Follo, Carlo, Savino, Miriam, Melone, Mariarosa A. B., Isidoro, Ciro·2016·Medicinal Research Reviews

DOI 10.1002/med.21394

Cited by (167)

Items 101–167 of 167

Repurposing the antimalarial chloroquine: a potential therapy for hepatic injury in a rat model of hindlimb ischemia–reperfusion by modulating apoptosis, autophagy, inflammation, and oxidative stress
Miar M Sherif, Hanan Salah El-Abhar, Hala M. Fawzy, Amany M. Gad, Dalaal M. Abdallah · 2025 · Future Journal of Pharmaceutical Sciences
Lysosomal Dysfunction in Amyotrophic Lateral Sclerosis: A Familial Case Linked to the p.G376D TARDBP Mutation
Roberta Romanò, Victoria Stefania Del Fiore, Giorgia Ruotolo, Martina Mazzoni, Jessica Diana Rosati, Francesca Luisa Conforti, Cecilia Bucci · 2025 · International Journal of Molecular Sciences
Prenatal‐onset of congenital neuronal ceroid lipofuscinosis with a novel CTSD mutation
Suzanne Chartier, Lucile Boutaud, Édouard Le Guillou, Caroline Alby, Clarisse Billon, A. Millischer, Catherine Caillaud, Louise Galmiche, Charlotte Mechler, Pascale Sonigo et al. · 2021 · Birth Defects Research
Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease
Rowan Gurney, Yvonne S. Davidson, Andrew Robinson, Anna M. T. Richardson, Matthew S. Jones, Julie S. Snowden, David M. A. Mann · 2018 · Neuropathology
Value of blood neural cell-derived small extracellular vesicles in the diagnosis and prediction of Alzheimer's disease: A systematic review
Weibing Pan, Yu Teng, Xiaowan Han, Shaojiao Liu, Xingxue Pang, Lei Wang, Mingjing Zhao · 2025 · The Journal of Prevention of Alzheimer s Disease
Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia et al. · 2026 · Advanced Science
Increased peripheral of brain-derived neurotrophic factor levels in phenylketonuric patients treated with l-carnitine
Jéssica Lamberty Faverzani, Gilian Guerreiro, Tatiane Grazieli Hammerschmidt, Franciele Fátima Lopes, Daniella de Moura Coelho, Ângela Sitta, Caroline Paula Mescka, Marion Deon, Moaçir Wajner, Carmen Regla Vargas · 2023 · Archives of Biochemistry and Biophysics
Total Syntheses of Cathepsin D Inhibitory Izenamides A, B, and C and Structural Confirmation of Izenamide B
Changjin Lim · 2019 · Molecules
Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability
Zhi Li, Hang Li, Fan Jiang, Zhaolin Wang, Wei Zhang · 2022 · Bioorganic & Medicinal Chemistry
“Micro-managing” immune activation and protein turnover: microglial lysosomes in the context of health and disease
Elizabeth A Somodji, Swetha Gowrishankar · 2026 · npj Dementia
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux
Fan Wu, Chunlan Li, Xianrang Song, Li Xie · 2025 · Cellular Signalling
Inhibiting TRPV4 improves α-synuclein degradation through autophagy-lysosomal pathway in the MPP+-induced cell model of parkinson’s disease
Yuncheng Bai, Hui Zang, Zhengbin Chen, Renwan Yin, Wen Jing Yang, Jia Luo, Qingjie Ma, Na Liu · 2025 · Scientific Reports
Functional Analysis of the Cathepsin D Gene Response to SGIV Infection in the Orange-Spotted Grouper, Epinephelus coioides
Yuexuan Wang, Honglin Han, Ke-Cheng Zhu, Suifeng Xu, Chengzong Han, Yunxiang Jiang, Shina Wei, Qiwei Qin · 2022 · Viruses
Lysosomal proteases and their role in signaling pathways
Samuel J. Bose, Thamali Ayagama, Rebecca A.B. Burton · 2021 · Elsevier eBooks
Associations of serum neuromarkers with clinical features of Parkinson’s disease
М. А. Никитина, Ekaterina S. Koroleva, N. G. Brazovskaya, A. S. Boyko, Lyudmila A. Levchuk, Svetlana А. Ivanova, Valentina Mikhailovna Alifirova · 2024 · S S Korsakov Journal of Neurology and Psychiatry
Studies on the Role of MAP4K2, SPI1, and CTSD in Osteoporosis
Chao Sun, Wanxiong He, Leipeng Wang, Ting Hao, Xiaolong Yang, Wei Feng, Yonggang Wu, Chenyang Meng, Zhi Wang, Xiaofeng Chen et al. · 2024 · Cell Biochemistry and Biophysics
Sappanin-type homoisoflavonoids from Scilla nervosa inhibits acetylcholinesterase enzyme: a combined in silico and in vitro approach
Samson Oluwaseyi Famuyiwa, Rajesh B. Patil, Kolade Olatubosun Faloye, Iyanu Oluwafemi Awotuya, Sandeep P. Gadhawe, Oluyemi J. Oladiran, Oyenike Idayat Bello · 2023 · Journal of Biomolecular Structure and Dynamics
Neuronal lipofuscinosis caused by Kufs disease/CLN4 DNAJC5 mutations but not by a CSPα/DNAJC5 deficiency
Santiago López-Begines, Nozha Borjini, Ángela Lavado-Roldán, Cristina Mesa-Cruz, Fabiola Mavillard, Vera I. Wiersma, Fátima Rubio-Pastor, Emanuela Tumini, Carmen Paradela‐Leal, María L. Chiclana-Valcárcel et al. · 2025 · Science Advances
Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease
Ralph A. Nixon, Ju‐Hyun Lee, Philip H. Stavrides, Sandipkumar Darji, Chris N. Goulbourne, Martin J. Berg, Panaiyur S. Mohan, Dun‐Sheng Yang, Panos Roussos, Cynthia Bleiwas et al. · 2024 · Research Square
Morpholine Anchored Fluorogenic Toolkit: Unveiled Disease Allied Protein Fibrillation in Lysosomal Compartment of Live‐Cell and Drosophila Models
P. Kavyashree, Harry Wilson, Akshay Silswal, Lopamudra Mishra, Debapriya Bhattacharya, Monalisa Mishra, Apurba Lal Koner · 2024 · Small
Antiretroviral Drugs Impact Autophagy Differently in Primary Human Astrocytes
Laura Cheney, Grace McDermott, Hillary M. Guzik, Joan W. Berman · 2025 · Cells
Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation
Hyun Su Kim, Hyejin Kong, Taewoo Kim, Changjin Lim, Seungbeom Lee, Seok‐Ho Kim, Young‐Ger Suh · 2023 · Marine Drugs
Molecular Differentiation of Cathepsins B and D, and of p53 Protein, and their Quantitative Assay in Biological Samples
Alexandru Adrian Bratei, Raluca‐Ioana Stefan‐van Staden, Ruxandra‐Maria Ilie‐Mihai, Damaris‐Cristina Gheorghe · 2023 · Journal of The Electrochemical Society
Bioinformatics Analysis of Oxidative Stress-Related Genes and Immune Infiltration Patterns in Vitiligo
Mingmei Yang, Huiying Wang, Ruzhi Zhang · 2025 · Clinical Cosmetic and Investigational Dermatology
Deciphering the dynamics of cathepsin D as a potential drug target to enhance anticancer drug-induced apoptosis
Syed Ainul Abideen, Murad Khan, Muhammad Irfan, Sajjad Ahmad · 2022 · Journal of Molecular Liquids
Absence of association of the Ala58Val (rs17571) CTSD gene variant with Parkinson’s disease or amyotrophic lateral sclerosis in a Han Chinese population
Jing Xi, Xinglong Yang, Quanzhen Zhao, Jinhua Zheng, Ran An, Sijia Tian, Hongyan Huang, Fayunn Hu, Pingping Ning, Yanming Xu · 2017 · Neuroscience Letters
Neurodegenerative Diseases and Autophagy
Angeleen Fleming, Mariella Vicinanza, Maurizio Renna, Claudia Puri, Thomas Ricketts, Jens Füllgrabe, Ana López, Sarah M. de Jager, Avraham Ashkenazi, Mariana Pavel Tanasa et al. · 2018 · Elsevier eBooks
The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease
Juan Yang, Xiaoting Ding, Shasha Meng, Jinhua Cai, Weihui Zhou · 2021 · Molecular Genetics & Genomic Medicine
The many roles of cathepsins in restenosis
Hai Long Wang, Megumi Narisawa, Pan Wu, Xiangkun Meng, Xian Wu Cheng · 2024 · Heliyon
Markers of Neurodegeneration in Parkinson’s Disease
М. А. Никитина, Valentina Mikhailovna Alifirova, S. O. Borodina, Ekaterina S. Koroleva · 2023 · Нейрохимия
Extracellular α‐synuclein impairs sphingosine 1‐phosphate receptor type 3 ( S1PR3 )‐regulated lysosomal delivery of cathepsin D in HeLa cells
Susumu Nishida, Shubi Ambwene Matovelo, Taketoshi Kajimoto, Shun‐ichi Nakamura, Taro Okada · 2024 · Genes to Cells
Effects of the continuous theta-burst stimulation on the levels of peripheral blood neuroplasticity biomarkers in people with obsessive-compulsive disorder: Findings from an open-label trial
Julian Maciaszek, Agnieszka Zabłocka, Maksymilian Rejek, Adrianna Senczyszyn, Kamila Rudy, Marta Błoch, Aleksandra Bubniak, Katarzyna Leszynska, Dominika Jakubczyk, Bogna Bogudzińska et al. · 2025 · Journal of Psychiatric Research
Alterations in the Na+/H+ Exchanger NHE6 and Glutamate Transporters may Influence Purkinje Cell Fate in ARSACS
Louis-Charles Masson, Atchaya S Kanagasabai, Brenda Toscano‐Márquez, Julia Tourbina-Kolomiets, François M. Charron, Alanna Jean Watt, Rebecca Anne McKinney · 2025 · The Cerebellum
A Differential Proteomic Analysis on Patient Sera with Neuromyelitis Spectrum Disorders (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Suggested Shared and Distinct Disease Mechanisms
Xueqiang Hu, Xiaobo Sun, Tingting Yang, Xiaoou Sun, Meiling Wen, Changming Chen, Wei Qiu, Ya Jin · 2025 · Journal of Proteome Research
Antigen processing and presentation through MHC molecules
Tâmisa Seeko Bandeira Honda, Bárbara Nunes Padovani, Niels Olsen Saraiva Câmara · 2021 · Elsevier eBooks
Protein–Protein Interactions in Neurodegenerative Diseases
Krishna Mohan Poluri, Khushboo Gulati, Deepak Kumar Tripathi, Nupur Nagar · 2023 · Springer eBooks
Pro-cathepsin D prevents aberrant protein aggregation dependent on endoplasmic reticulum protein CLN6
Yuki Shiro, Syouichi Katayama, Haruka Tsukamoto, Tetsuo Yamazaki · 2024 · Molecular Genetics and Metabolism
Insights into Octopus maya cathepsins from metatranscriptome and genome: structure evolutionary relationships and functional role prediction in digestive processes
Daisy Pineda-Suazo, Francisco Guillén-Chable, Wendy Escobedo‐Hinojosa, Clara E. Galindo‐Sánchez, Carlos Rosas · 2025 · Biology Open
Molecular characterization and functional analysis of the lysosomal cathepsin D-like gene in red swamp crayfish, Procambarus clarkii
Long Huang, Benli Wu, Jixiang He, Ye Zhang, Jing Chen, Xia-jun Chen · 2021 · Genome
Implication of Galectin-3 for Neuroinflammation in the Visual Pathway of the Experimental Optic Neuritis
Masako Funaki, Junko Nio‐Kobayashi, Ryoji Suzuki, Yoshio Bandô · 2023 · Preprints.org
Neuronal cell line expressing full-length mutant huntingtin displays alteration of proteasome activity
Natalia N. Gotmanova, Tatiana V. Bobik, Alexander A. Ezhov, Anna A. Valyaeva, Maria I. Zvereva, Maria P. Rubtsova, Anna V. Bacheva · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Batten Disease - Beyond the Blind Spots
Willemijn F. E. Kuper · 2020
Curcumin in Parkinson’s disease treatment
Magisetty Obulesu · 2021 · Elsevier eBooks
Regulation of Intestinal Microbiota as a Therapeutic Target for Neuroinflammatory Diseases in Persistent COVID
Diana Matías-Pérez, Iván Antonio García-Montalvo · 2021 · Archives of Neuroscience
Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice
Denise Ming Tse Yu, Stephanie Dauth, Michael Bogdan Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix · 2022 · Applied Sciences
Supplement (online only): Proceedings of the 14th Göttingen Meeting of the German Neuroscience Society 2021
Giedrius Steponaitis, Kučinskas, Vytautas, Aušra Saudargienė, Arimantas Tamašauskas · 2021 · e-Neuroforum
Pathophysiology of Lysosomes in a Nutshell
Ciro Isidoro · 2023 · International Journal of Molecular Sciences
Markers of Neurodegeneration in Parkinson’s Disease
М. А. Никитина, Valentina Mikhailovna Alifirova, S. O. Borodina, Ekaterina S. Koroleva · 2023 · Neurochemical Journal
Axonal transport of autophagosomes in models of neurodegeneration in vitro and in vivo
Luo, Xiaoyue · 2023
Characterization, expression profiling, and immunological role of Cathepsin D in Sebastes schlegelii during bacterial infection
Xuan Xu, Yiying Liu, Xingchun Li, Pei Zhang, Feng Lin, Chonghui Chen, Xiaoxu Zhang, Chao Li, Qiang Fu · 2025 · Developmental & Comparative Immunology
Protein biomarker discovery for canine cognitive dysfunction syndrome based on molecular alterations observed in nasal fluids
Jiwon Chae, Mina Choi, Juyoung Choi, Seung‐Jun Yoo · 2025 · Research Square
A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses
Ruiping Tang, Charles-Francois Vincent Latchoumane, Avi Chopra, Md Marzan Sarkar, CK Kim, Nathan Gonsalves, Hsueh‐Fu Wu, John C. Sentmanat, Alan Liu, Isha Mhatre‐Winters et al. · 2026 · Advanced Healthcare Materials
Astrocytic Cathepsin D truncates α-synuclein and promotes Lewy neurite-like aggregation in neurons
Hiroshi Hanafusa, Kota Ohashi, Hiromu Shojima, Naoki Hisamoto, Takeshi Kameyama, Muneaki Miyata, Kiyohito Mizutani, Yoshimi Takai, Kunihiro Matsumoto · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Bidirectional causal association between cathepsins and neuropsychiatric disorders: univariate and multivariate Mendelian randomization study
Zeyang Li, Lei Jia, Shengnan Huai · 2025 · European Archives of Psychiatry and Clinical Neuroscience
The blood proteome predicts the impact of circulating factors on age-related mitochondrial health
Stephanie Heimler, Jaclyn Bergstrom, Nina Sun, Toshiko Tanaka, Ann Zenobia Moore, Julián Candia, Brian H. Chen, Qu Tian, Arsun Bektas, Giovanna Fantoni et al. · 2026 · npj Aging
Chlorogenic acid promotes the degradation of advanced glycation end-products in skin via transcription factor EB mediated autophagy-lysosomal pathway
Yuhang Zhu, Zhangtie Wang, Baiyi Lu · 2026 · Food Bioscience
Brucella abortus Inhibits SIRT1 to Modulate Intracellular Survival and Autophagy in Macrophages
Yuanhao Yang, Lin Qi, MengYu Zhang, Junmei Li, Mingyue Hao, J. Chen, X Liu, Gaowa Wudong, Dong Zhou, Wei Liu et al. · 2026 · Transboundary and Emerging Diseases
Aerobic exercise intervention in Alzheimer's disease: Proteomic insights into peripheral T cell–mediated immune pathways
Xing Ye, Kai Tang Hu, Renyi Liu · 2026 · Journal of Alzheimer s Disease
Caractérisation fonctionnelle et exploration du spectre phénotypique de gènes responsables de malformations cérébrales
Lucile Boutaud · 2021 · theses.fr (ABES)
Association of Cathepsin Proteins with Alzheimer's Disease Risk: An Integrated Observational and Genetic Analysis
Qianlong Zhang, Qingyang Li, Zisheng Ai, Feng Li, Yi Wang, Wei Zhou · 2026 · NeuroMolecular Medicine
Unveiling the role of lysosomes in antigen processing and presentation
Gabriele Sergio Colangelo, Kyra J. Cowan, Federico Riccardi Sirtori, Luca Maria Barbero · 2026 · The Journal of Immunology
Cathepsin D as a central regulator of extracellular matrix remodeling in wound healing and chronic tissue pathologies.
S. Rangappa, Thammanna Gowda Ss, Parimala Hanumesh, P. K., Manjula Rv · 2026 · Tissue Barriers
Macrophage TMEM175‐Mediated Transcriptional Regulation of Cathepsins Drives Bacterial Killing in Sepsis
Zhenzhen Bai, Bei Peng, Tao Luo, Lingbin Sun · 2026 · Journal of Immunology Research
Astrocytic cathepsin D promotes α-synuclein processing and Lewy neurite-like aggregate maturation
Hiroshi Hanafusa, Kota Ohashi, Hiromu Shojima, Yurika Honda, Naoki Hisamoto, Takeshi Kameyama, Muneaki Miyata, Kiyohito Mizutani, Yoshimi Takai, Kunihiro Matsumoto · 2026 · EMBO Reports
BindingDB Entry 50007120: Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
BindingDB · 2021 · UC San Diego
BindingDB Entry 50002926: Design, synthesis, and biological evaluation of polo-like kinase 1/eukaryotic elongation factor 2 kinase (PLK1/EEF2K) dual inhibitors for regulating breast cancer cells apoptosis and autophagy.
BindingDB · 2020 · UC San Diego
BindingDB Entry 50017632: Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability.
BindingDB · 2023 · UC San Diego