Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery

Ni, Duan, Lu, Shaoyong, Zhang, Jian·2019·Medicinal Research Reviews

Cited by (121)

Items 101–121 of 121

  1. Quantifying Protein-Protein Interaction with a Spatial Attention Kinetic Graph Neural Network
    Yuzhi Xu, Wei Xia, Chao Zhang, Xinxin Liu, Cheng‐Wei Ju, Xuhang Dai, Pujun Xie, Yuanqing Wang, Guangyong Chen, John Z. H. Zhang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Small Molecule Inhibitors Targeting Protein–Protein Interactions in the BCL Protein
    Wenhua Zhu, Yangbo He, Gang Chen, Di Zhu · 2025 · Wiley eBooks
  3. Computational Design of Therapeutic Peptides
    Priyanka Ray Choudhury, Siddharth Yadav, Shivika Jaiswal, Tushita Khanna, Puniti Mathur · 2025 · BENTHAM SCIENCE PUBLISHERS eBooks
  4. Drug Delivery System for the Anticancer Drug Paclitaxel Using Lipocalin-Type Prostaglandin D Synthase Conjugated to a Tumor-Targeting Peptide
    Kousuke Furuta, Masatoshi Nakatsuji, Haruna Yoshida, Rina Okubo, Keisuke Nishide, Takaki Yamamura, Takashi Inui · 2026 · ACS Omega
  5. Computational Methods and Tools for the Design and Development of Small Molecule Inhibitors Targeting PPIs
    Arpan Chowdhury, Siva Murru · 2026 · Challenges and advances in computational chemistry and physics
  6. Agnostic Biomolecular Binding Affinity Prediction via Frame Averaging Graph Transformer
    Krinos Li, Lucas He, Xianglu Xiao, Shenglong Deng, Zijun Zhong, Yue Yang, Guang Yang · 2025 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  7. Protein-protein interaction inhibitors in cancer
    Ian Robert Hardcastle, Jennyfer Goujon-Ricci, William Isaac Thompson · 2026 · Elsevier eBooks
  8. Reinforcement Learning-Driven Conversion Designed Minibinders to Small Molecules Targeting Porcine Nectin-1 IgV Domain for Anti-PRV Therapy
    Zigong Wei, Lin Wei, Y. Angela Hu, Peng Chen, Yuhua Chen, Keke Wang, Jun Weng, Banbin Xing, Ke Ming, Zhiyong Wu et al. · 2026 · Research Square
  9. Pep2Mol: 3D Molecule Generation Targeting Protein-Protein Interfaces with Diffusion Models
    Rongting Yue, Zekun Yang, Gustavo de Miranda Seabra, Chenglong Li, Yanjun Li · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Targeting the IL-17A Cytokine Interface: Structural Insights and Small-Molecule Modulators
    Gyeong Un Kim, Ansoo Lee, Sanghee Lee, Byungsun Jeon, Hahnbeom Park, Taek Kang, Hyunah Choo · 2026 · Journal of Medicinal Chemistry
  11. BindingDB Entry 50016318: Medicinal Chemistry Strategies for the Development of Bruton's Tyrosine Kinase Inhibitors against Resistance.
    BindingDB · 2023 · UC San Diego
  12. BindingDB Entry 50012908: Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities.
    BindingDB · 2022 · UC San Diego
  13. BindingDB Entry 50018744: Fight against novel coronavirus: A perspective of medicinal chemists.
    BindingDB · 2024 · UC San Diego
  14. BindingDB Entry 50021951: Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity.
    BindingDB · 2025 · UC San Diego
  15. BindingDB Entry 50013821: Design, synthesis, evaluation, and SAR of 4-phenylindoline derivatives, a novel class of small-molecule inhibitors of the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) interaction.
    BindingDB · 2022 · UC San Diego
  16. BindingDB Entry 50013735: A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A.
    BindingDB · 2022 · UC San Diego
  17. BindingDB Entry 50019499: Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives.
    BindingDB · 2024 · UC San Diego
  18. BindingDB Entry 50018346: Computational methods-guided design of modulators targeting protein-protein interactions (PPIs).
    BindingDB · 2024 · UC San Diego
  19. BindingDB Entry 50022443: Design, synthesis, and biological evaluation of novel 4,4'-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer.
    BindingDB · 2025 · UC San Diego
  20. BindingDB Entry 50019184: Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED-H3K27me3 Inhibitors for the Treatment of Lymphoma.
    BindingDB · 2024 · UC San Diego
  21. BindingDB Entry 50021712: Recent Discovery and Development of Inhibitors that Target CDK9 and Their Therapeutic Indications.
    BindingDB · 2025 · UC San Diego