From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology

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Items 101–170 of 170

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4. Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer’s disease
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6. New highly efficient multifunctional cholinesterase inhibitors based on the conjugation of amiridine and tacrine homolog
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7. Conjugates of tacrine with aminomethylidene derivatives of ethyl acetoacetate as promising agents for the treatment of Alzheimer’s disease
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8. Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases
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10. Synthesis of New Hantzsch Adducts Showing Ca 2+ Channel Blockade capacity, Cholinesterase Inhibition and Antioxidant Power
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11. Latest Progress in the Development of Multitarget Ligands for Alzheimer's Disease Based on the Hantzsch Reaction
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12. Multi‐Target‐Directed Ligands ( MTDLs ) as Potential Therapeutic Candidates Targeting Multiple Pathogenic Factor of Alzheimer's Disease
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13. Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids
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14. Recent Molecular Targets and their Ligands for the Treatment of Alzheimer Disease
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15. Recent Advances in Alzheimer’s Disease in Relation to Cholinesterase Inhibitors and NMDA Receptor Antagonists
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16. Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
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17. Rivastigmine Templates with Antioxidant Motifs—A Medicinal Chemist’s Toolbox Towards New Multipotent AD Drugs
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18. Synthesis, biological evaluation, and in silico studies of pyridoxal-amiridine hybrids as multitargeting anti-Alzheimer's disease agents.
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19. From Molecular Networks to Medicines: Targeting Complexity in Alzheimer’s Disease (AD) Therapy
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20. Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
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21. In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors
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22. Features of Conjugation of Ipidacrine Chloroalkylamides with 5-Acetyl-3-(trifluoromethyl)pyrazole and Its Derivatives. Study of Biological Activity
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24. Computational design of new tacrine analogs: an in silico prediction of their cholinesterase inhibitory, antioxidant, and hepatotoxic activities
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25. Natural Plant Materials as a Source of Neuroprotective Peptides
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26. Design, synthesis, in silico , and in vitro evaluation of pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors
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33. New functions of cholinesterases in the development of Alzheimer’s disease as a target for neuroprotective drugs
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34. Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties
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37. Synthesis, spectral characterization, and cholinesterase inhibitory evaluation of benzothiazole-linked oxadiazole derivatives as potential anti-Alzheimer's agents
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39. Emerging Roles of Rivastigmine Derivatives Bearing Antioxidant Motifs as Multi-Target Agents for the Management of Neurodegenerative Diseases
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45. Enzymes | Monoamine Oxidase (EC 1.4.3.4)
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50. SEARCHING FOR MULTI-TARGET SUBSTANCES WITH ANTI-MICROBIAL EFFECT – PROMISING DIRECTION MODERN PHARMACEUTICAL SCIENCE
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51. Cholinesterase Inhibition for the Treatment of Neurodegenerative Diseases: Assay Methodologies and Reference Compounds
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52. New Series of Aromatic Amides Hybrids Derivatives as Anti-Alzheimer's Drugs: Design, Synthesis, Biological Activity and Computational Studies
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53. New series of aromatic amides hybrids derivatives as anti-Alzheimer's drugs: Design, synthesis, biological activity and computational studies
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56. First Sustainable One-Pot Tandem Hantzsch Multicomponent Reaction/Click Reaction Approach for Novel Multitarget-Directed Ligands in Alzheimer’s Disease
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66. Influence of N ‐Functionalization of Amiridine on the Biological Activity of Its Conjugates as Multitarget Agents for Potential Treatment of Alzheimer's Disease
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