Telomere length, family history, and paternal age in schizophrenia
Open accessAbstract
Leukocyte telomere length (LTL) is longer in association with advanced paternal age, but this association has not been examined along with family history (FH) in schizophrenia. LTL was measured by PCR and compared across cases and controls as part of a study to examine the characteristics of paternal age related schizophrenia. The 53 schizophrenia cases had similar mean LTL as 20 controls, although cases were significantly older than controls and overwhelmingly smoked cigarettes. Multivariate analyses showed that a FH of schizophrenia was associated with longer LTL in both male and female cases. Later paternal age was also related to longer LTL in male cases, but with shorter LTL in female cases. Male cases with older fathers and a FH had the longest LTL. The genetic architecture associated with a familial risk for schizophrenia may include pathways that lengthen LTL. Paternal aging conferred an additional increase in LTL lengthening in male cases, but reduced LTL in female cases. The gender difference in LTL for paternal aging is consistent with the severe illness features reported for female cases with older fathers and could implicate epigenetic alterations in the paternal X chromosomal region with advanced paternal age in association with the risk for schizophrenia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Malaspina et al. (2014) reported no significant difference in LTL between medicated individuals with schizophrenia compared to controls, but the control sample size was small and the psychiatric history of controls was assessed only for the preceding two years.
“Most recently, Malaspina et al. (2014) reported no significant difference in LTL between medicated individuals with schizophrenia compared to controls, but the control sample size was small, and the psychiatric history of the controls was assessed only for the preceding two years.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Malaspina et al. (2014)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 19 · Cited by 54
- Authors
- Malaspina, D., Dracxler, R., Walsh‐Messinger, J., Harlap, S., Goetz, R. R., Keefe, D., & Perrin, M. C.
- Affiliations
- Creedmoor Psychiatric Center (US)
- New York University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Malaspina, Dolores
- Venue
- Molecular Genetics & Genomic Medicine
- Publisher
- Wiley
- Published
- 2014-03-11
- Volume
- 2
- Issue
- 4
- Pages
- 326-331
- ISSN
- 2324-9269 (ISSN-L)
- PMC
- PMC4113273
- OpenAlex
- W2160032080
- Cited by
- 54
- References
- 19
- Citations by year
- 2025: 4 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 13 · 2014: 3
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Genetics & Genomic Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Mental Health (RC1MH088843-02, 2K24MH00169)
- NIH Clinical and Translational Science Awards Program (CTSA UL1 TR000038)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- schizophrenia, leukocyte telomere length, paternal age, family history (medicine), advanced paternal age, sex differences, epigenetics, X chromosome, smoking, genetic risk
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
