The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Reproductive toxicity of phthalate esters
Abstract
Phthalate esters are ubiquitous environmental contaminants that in general display low‐toxicity. Overall, the reproductive effects of these compounds are well characterized in adult's animals, with gonadal injury observed after high dose exposure. However, results of recent transgeneration studies indicate that the reproductive system of developing animals is particularly vulnerable to certain phthalates. The phenotypic alterations observed in male offspring rats exposed during the perinatal period have remarkable similarities with common human reproductive disorders, including cryptorchidism, hypospadias and low‐sperm counts. Recent results also indicate that high phthalate doses can adversely affect adult and developing female rats. However, the main question involving phthalates is whether the current level of human exposure is sufficient to adversely affect male and/or female reproductive health. Here, we review the reproductive toxicity data of phthalates in adult and developing animals as well as possible modes of action. In addition, we briefly discuss the relevance of animal studies to humans in light of recent epidemiological data and experimental research with low (human relevant) doses. Finally, we point out some critical issues that should be addressed in order to clarify the implications of phthalates for human reproduction.
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Decrease in anogenital distance among male infants with prenatal phthalate exposure
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Mechanisms of phthalate ester toxicity in the female reproductive system.
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Guo, Y., & Kannan, K. (2013) · Environmental Science & Technology · doi:10.1021/es4042034 · Cited by 627
Giulivo, M., Lopez de Alda, M., Capri, E., & Barceló, D. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.011 · Cited by 573
Delcuve, G. P., Khan, D. H., & Davie, J. R. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-5 · Cited by 505
Phthalates and Parabens in Personal Care Products From China: Concentrations and Human Exposure
Guo, Y., Wang, L., & Kannan, K. (2014) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-013-9937-x · Cited by 345
Metadata
- Authors
- Martino‐Andrade, A. J., & Chahoud, I.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 54
- Issue
- 1
- Pages
- 148-157
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1980615604
- Cited by
- 347
- References
- 82
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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