The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Multi-parametric approach to identify coffee components that regulate mechanisms of gastric acid secretion
Abstract
Scope: Chlorogenic acid (CA), caffeine (CAFF), pyrogallol (PYR), catechol (CAT), βN‐alkanoyl‐hydroxytryptamides (C5HT) and N‐methylpyridinium (N‐MP) were evaluated for their influence on mechanisms of gastric acid secretion as single compounds and in biomimetic mixtures. Methods and results: Compounds were tested in coffee representative concentrations. Human gastric cancer cells (HGT‐1) were used to study the proton secretory activity by Ussing chamber experiments and FACS analysis. For activation of EGFr, Akt1, ERK1/2, ATF‐2 and cAMP levels, we performed pathway screening assays. Time‐dependent expression of related genes were determined by real‐time PCR. Part of the data was used for neural network modeling to identify the most relevant compounds. N‐MP increased the expression of the anti‐secretory somatostatin receptor by 114%, whereas C5HT decreased its expression by 52%. N‐MP down‐regulated the pro‐secretory CHRM3 receptor by 36% and the H+,K+‐ATPase by 36%. CAFF stimulated the secretory activity in the functional assays, whereas N‐MP and CA decreased proton secretion. After applying a pathway analysis, we were able to discriminate between CAFF, CA, CAT, C5HT, PYR and histamine‐activating EGFr signaling and N‐MP‐associated ERK1/2 signaling. Conclusion: By applying a multi‐parametric approach, N‐MP was shown to effectively down‐regulate mechanisms of gastric acid secretion in human parietal gastric cells.
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“This effect depends on the degree of roasting, with dark roasted coffee being less effective in stimulating gastric acid release, possibly because of the presence of a higher amount of N-methylpyridinium and smaller amounts of chlorogenic acids, trigonelline, and βN-alkanoyl-5-hydroxytryptamides (C5HTs).”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [16]
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Cites
Coffee and Gastrointestinal Function: Facts and Fiction: A Review
J. Boekema, M. S. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025525 · Cited by 164
Coffee Consumption and Stomach Cancer Risk in a Cohort of Swedish Women
Larsson, S. C., Giovannucci, E., & Wolk, A. (2006) · International Journal of Cancer · doi:10.1002/ijc.22105 · Cited by 42
Rubach, M., Lang, R., Skupin, C., Hofmann, T., & Somoza, V. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf904493f · Cited by 31
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Cited by
Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update
Nehlig, A. (2022) · Nutrients · doi:10.3390/nu14020399 · Cited by 158
Papakonstantinou, E., Kechribari, I., Sotirakoglou, Κ., Tarantilis, P., Gourdomichali, T., Michas, G., Kravvariti, V., Voumvourakis, K., & Zampelas, A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0146-0 · Cited by 59
“In some studies, the coffee-mediated increased gastric acid secretion [4] has been associated with GI disturbances, such as gastroesophageal reflux disease (GERD), epigastric pain, reflux, and heartburn [5].”
BackgroundOleaga, C., Ciudad, C. J., Noé, V., & Izquierdo-Pulido, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/390385 · Cited by 25
“The downregulation of ATF-2 expression after CA and ICC incubation in HT29 cells reported here is in accordance with the observed decrease in activity of ATF-2 in gastric cells when incubating with chlorogenic acid, the precursor of caffeic acid [64].”
BackgroundResultInfluential
Metadata
- Authors
- Rubach, M., Lang, R., Seebach, E., Somoza, M. M., Hofmann, T., & Somoza, V.
- Affiliations
- German Research Center for Food Chemistry Freising Germany
- Chair of Food Chemistry and Molecular and Sensory Science Technische Universität München Freising Germany
- University of Wisconsin, Department of Food Science Madison WI USA
- Institute for Inorganic Chemistry University of Vienna Austria
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2012-02
- Volume
- 56
- Issue
- 2
- Pages
- 325-335
- ISSN
- 1613-4125
- 1613-4133
- Cited by
- 30
- References
- 3
- Language
- en
- Funders
- FEI
- AiF
- German Ministry of Economics (14042 N)
- German Academic Exchange Service
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