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Systematic review of chorioamnionitis and cerebral palsy

Wu, Yvonne W.·2002·Mental Retardation and Developmental Disabilities Research Reviews

Abstract

In a recent meta‐analysis evaluating the relationship between chorioamnionitis and cerebral palsy, we found that chorioamnionitis is a risk factor for both cerebral palsy and cystic periventricular leukomalacia (cPVL). The current paper extends the meta‐analysis by including studies published in the year 2000, and by further evaluating the causes of heterogeneity among individual study results. Using a random effects model, clinical chorioamnionitis was significantly associated with both cerebral palsy (RR 1.9, 95% CI 1.5–2.5) and cPVL (RR 2.6, 95% CI 1.7–3.9). Sources of heterogeneity included widely varying practices in the diagnosis of clinical chorioamnionitis, different gestational age characteristics, and varying study year. We conclude that based on the available literature, chorioamnionitis is a risk factor for both cerebral palsy and cPVL. MRDD Research Reviews 2002;8:25–29. © 2002 Wiley‐Liss, Inc.

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Metadata

Authors
Wu, Y. W.
Venue
Mental Retardation and Developmental Disabilities Research Reviews
Publisher
Wiley
Published
2002-01
Volume
8
Issue
1
Pages
25-29
ISSN
  • 1080-4013 (ISSN-L)
  • 1098-2779
OpenAlex
W2021558565
Cited by
230
References
1
FWCI
2.71
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Systematic review of chorioamnionitis and cerebral palsy. https://app.cochat.ai/papers/10.1002/mrdd.10003
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Wu, Y. W. (2002). Systematic review of chorioamnionitis and cerebral palsy. Mental Retardation and Developmental Disabilities Research Reviews. https://doi.org/10.1002/mrdd.10003

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