Anisotropy in high angular resolution diffusion-weighted MRI
Open accessAbstract
The diffusion in voxels with multidirectional fibers can be quite complicated and not necessarily well characterized by the standard diffusion tensor model. High angular resolution diffusion‐weighted acquisitions have recently been proposed as a method to investigate such voxels, but the reconstruction methods proposed require sophisticated estimation schemes. We present here a simple algorithm for the identification of diffusion anisotropy based upon the variance of the estimated apparent diffusion coefficient (ADC) as a function of measurement direction. The rationale for this method is discussed, and results in normal human subjects acquired with a novel diffusion‐weighted stimulated‐echo spiral acquisition are presented which distinguish areas of anisotropy that are not apparent in the relative anisotropy maps derived from the standard diffusion tensor model. Magn Reson Med 45:935–939, 2001. Published 2001 Wiley‐Liss, Inc.
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HARDI acquires diffusion-weighted data along many more directions than the minimum six required for tensor estimation.
“To mitigate the single-tensor crossing-fiber limitation, high-angular-resolution diffusion imaging (HARDI) acquires diffusion-weighted data along many more directions than the minimum six required for tensor estimation (Frank, 2002).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Frank, 2002
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- Authors
- Frank, L. R.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Frank, Lawrence R.
- ORCID
- Frank, Lawrence R.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2001-05-23
- Volume
- 45
- Issue
- 6
- Pages
- 935-939
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2086858670
- Cited by
- 389
- References
- 26
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 14 · 2013: 26 · 2012: 19
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- Locations
- Magnetic Resonance in Medicine (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- diffusion anisotropy, white matter fiber orientation
- MeSH terms
- Algorithms, Brain, Diffusion, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Reference Values, Anisotropy
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