The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Quantitation of blood‐brain barrier defect by magnetic resonance imaging and gadolinium‐DTPA in patients with multiple sclerosis and brain tumors
Abstract
In this study quantitation of the degree of deficiency of the blood‐brain barrier (BBB) in patients with multiple sclerosis or brain tumors, by using MRI, is shown to be possible. As a measure of permeability of the BBB to Gadolinium‐DTPA (Gd‐DTPA) the flux per unit of distribution volume per unit of brain mass was used. This quantity was found by introducing the longitudinal relaxation rate (R1) as a measure of concentration of Gd‐DTPA in the brain tissue in the mathematical model for the transcapillary transport over the BBB. High accordance between the observed data points and the model was found, and the results were comparable to results obtained from similar studies using positron emission tomography. The improved possibility of quantitating the defect of the BBB by MRI may give new information about pathogenesis or etiology, and leads to improved methods in monitoring the efficacy of treatments in intracranial diseases. © 1990 Academic Press, Inc.
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Cites
Patlak, C. S., & Blasberg, R. G. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.87 · Cited by 1,673
Crone, C. (1963) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1963.tb02652.x · Cited by 1,153
Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles
Renkin, E. M. (1959) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1959.197.6.1205 · Cited by 723
Gadolinium-DTPA as a Contrast Agent in MR Imaging—Theoretical Projections and Practical Observations
Gadian, D., Payne, J. A., Bryant, D. J., et al. (1985) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198503000-00003 · Cited by 156
Juhler, M., Barry, D. I., Offner, H., Konat, G. W., Klinken, L., & Paulson, O. B. (1984) · Brain Research · doi:10.1016/0006-8993(84)90249-x · Cited by 131
Self-citationLarsson, H. B. W., Frederiksen, J. L., Kjær, L., Henriksen, O. M., & Olesen, J. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910070106 · Cited by 129
Self-citationMultiple sclerosis disease activity correlates with gadolinium‐enhanced magnetic resonance imaging
González‐Scarano, F., Grossman, R. I., Galetta, S., Atlas, S. W., & Silberberg, D. H. (1987) · Annals of Neurology · doi:10.1002/ana.410210312 · Cited by 100
The use of GD DTPA as a perfusion agent and marker of blood-brain barrier disruption
Runge, V. M., Clanton, J. A., Price, A. C., Wehr, C. J., Herzer, W. A., Partain, C. L., & James, A. E. (1985) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(85)90008-6 · Cited by 88
Simplified, noninvasive PET measurement of blood-brain barrier permeability.
Iannotti, F., Fieschi, C., Alfano, B., Picozzi, P., Mansi, L., Pozzilli, C., Punzo, A., del Vecchio, G., Lenzi, G. L., & Salvatore, M. (1987) · Journal of computer assisted tomography · doi:10.1097/00004728-198705000-00004 · Cited by 80
MR pulse sequences for selective relaxation time measurements: A phantom study
Thomsen, C. E., Jensen, K. E., Jensen, M., Olsen, E. R., & Henriksen, O. (1990) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(90)90211-j · Cited by 39
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Cited by
Tofts, P. S., Brix, G., Buckley, D. L., Evelhoch, J. L., Henderson, E., Knopp, M. V., Larsson, H. B. W., Lee, T.-Y., Mayr, N. A., Parker, G. J. M., et al. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s · Cited by 3,143
Self-citationLeach, M. O., Brindle, K. M., Evelhoch, J. L., Griffiths, J. R., Horsman, M. R., Jackson, A., Jayson, G. C., Judson, I. R., Knopp, M. V., Maxwell, R. J., et al. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602550 · Cited by 513
Classic models for dynamic contrast‐enhanced MRI
Sourbron, S. P., & Buckley, D. L. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2940 · Cited by 434
Texture Analysis: A Review of Neurologic MR Imaging Applications
Kassner, A., & Thornhill, R. E. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2061 · Cited by 408
Heye, A. K., Culling, R. D., Valdés Hernández, M. D. C., Thrippleton, M. J., & Wardlaw, J. M. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.09.002 · Cited by 406
Metadata
- Authors
- Larsson, H. B. W., Stubgaard, M., Frederiksen, J. L., Jensen, M., Henriksen, O., & Paulson, O. B.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1990-10
- Volume
- 16
- Issue
- 1
- Pages
- 117-131
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1965728888
- Cited by
- 431
- References
- 11
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Quantitation of blood‐brain barrier defect by magnetic resonance imaging and gadolinium‐DTPA in patients with multiple sclerosis and brain tumors. https://app.cochat.ai/papers/10.1002/mrm.1910160111
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- Larsson, H. B. W., Stubgaard, M., Frederiksen, J. L., Jensen, M., Henriksen, O., & Paulson, O. B. (1990). Quantitation of blood‐brain barrier defect by magnetic resonance imaging and gadolinium‐DTPA in patients with multiple sclerosis and brain tumors. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910160111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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