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Experimentally‐derived functional form for a population‐averaged high‐temporal‐resolution arterial input function for dynamic contrast‐enhanced MRI

Open access
Parker, Geoff J.M., Roberts, Caleb, Macdonald, Andrew, Buonaccorsi, Giovanni A., Cheung, Sue, Buckley, David L., Jackson, Alan, Watson, Yvonne, Davies, Karen, Jayson, Gordon C.·2006·Magnetic Resonance in Medicine

Abstract

Rapid T1‐weighted 3D spoiled gradient‐echo (GRE) data sets were acquired in the abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast‐enhanced MRI (DCE‐MRI) analysis of tumor microvasculature. The arterial input function (AIF) was measured in each patient at each visit using an automated AIF extraction method following a standardized bolus administration of gadodiamide. The AIFs for each patient were combined to obtain a mean AIF that is representative for any individual. The functional form of this general AIF may be useful for studies in which AIF measurements are not possible. Improvements in the reproducibility of DCE‐MRI model parameters (Ktrans, ve, and vp) were observed when this new, high‐temporal‐resolution population AIF was used, indicating the potential for increased sensitivity to therapy‐induced change. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.

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Metadata

Authors
Parker, G. J. M., Roberts, C., Macdonald, A., Buonaccorsi, G. A., Cheung, S., Buckley, D. L., Jackson, A., Watson, Y., Davies, K., & Jayson, G. C.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2006-10-11
Volume
56
Issue
5
Pages
993-1000
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2089513130
Cited by
660
References
0
FWCI
14.61
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Experimentally‐derived functional form for a population‐averaged high‐temporal‐resolution arterial input function for dynamic contrast‐enhanced MRI. https://app.cochat.ai/papers/10.1002/mrm.21066
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Parker, G. J. M., Roberts, C., Macdonald, A., Buonaccorsi, G. A., Cheung, S., Buckley, D. L., Jackson, A., Watson, Y., Davies, K., & Jayson, G. C. (2006). Experimentally‐derived functional form for a population‐averaged high‐temporal‐resolution arterial input function for dynamic contrast‐enhanced MRI. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.21066

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