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Cited by 53Advanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and ApplicationsNMR spectroscopy and applications

Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: Application to adrenomyeloneuropathy

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Smith, Seth A., Golay, Xavier, Fatemi, Ali, Mahmood, Asif, Raymond, Gerald V., Moser, Hugo W., van Zijl, Peter C.M., Stanisz, Greg J.·2009·Magnetic Resonance in Medicine
DOI 10.1002/mrm.21827PMC PMC2632947
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Abstract

Magnetization transfer (MT) imaging has assessed myelin integrity in the brain and spinal cord; however, quantitative MT (qMT) has been confined to the brain or excised tissue. We characterized spinal cord tissue with qMT in vivo, and as a first application, qMT‐derived metrics were examined in adults with the genetic disorder Adrenomyeloneuropathy (AMN). AMN is a progressive disease marked by demyelination of the white matter tracts of the cervical spinal cord, and a disease in which conventional MRI has been limited. MT data were acquired at 1.5 Tesla using 10 radiofrequency offsets at one power in the cervical cord at C2 in 6 healthy volunteers and 9 AMN patients. The data were fit to a two‐pool MT model and the macromolecular fraction (M ob ), macromolecular transverse relaxation time (T 2b ) and the rate of MT exchange (R) for lateral and dorsal column white matter and gray matter were calculated. M ob for healthy volunteers was: WM = 13.9 ± 2.3%, GM = 7.9 ± 1.5%. In AMN, dorsal column M ob was significantly decreased ( P < 0.03). T 2b for volunteers was: 9 ± 2 μs and the rate of MT exchange (R) was: WM = 56 ± 11 Hz, GM = 67 ± 12 Hz. Neither T 2b nor R showed significant differences between healthy and diseased cords. Comparisons are made between qMT, and conventional MT acquisitions. Magn Reson Med 61:22–27, 2009. © 2008 Wiley‐Liss, Inc.

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  • Magnetization transfer or diffusion tensor-based imaging sequences can detect abnormalities in spinal cord tracts in X-ALD.

    “Magnetization transfer or diffusion tensor-based imaging sequences can detect abnormalities in spinal cord tracts [65,97,98].”

    From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [97]

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Research works printed but not linked: 27

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Authors
Smith, S. A., Golay, X., Fatemi, A., Mahmood, A., Raymond, G. V., Moser, H. W., van Zijl, P. C. M., & Stanisz, G. J.
Affiliations
  • Kennedy Krieger Institute (US)
  • Johns Hopkins University (US)
  • Sunnybrook Health Science Centre (CA)
Corresponding author
Smith, Seth A.
ORCID
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2008-12-18
Volume
61
Issue
1
Pages
22-27
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.21827
PMC
PMC2632947
OpenAlex
W2064981815
Cited by
53
References
0
Citations by year
2026: 1 · 2025: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
NIH/NCRR (RR015241)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
quantitative magnetization transfer, adrenomyeloneuropathy, cervical spinal cord, myelin integrity, demyelination, macromolecular fraction, white matter, gray matter
MeSH terms
Adrenoleukodystrophy, Adult, Algorithms, Cervical Vertebrae, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Middle Aged, Nerve Fibers, Myelinated, Sensitivity and Specificity, Spinal Cord, Reproducibility of Results

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