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Cited by 117Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applications

Probing mouse brain microstructure using oscillating gradient diffusion MRI

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Aggarwal, Manisha, Jones, Melina V., Calabresi, Peter A., Mori, Susumu, Zhang, Jiangyang·2012·Magnetic Resonance in Medicine
DOI 10.1002/mrm.22981PMC PMC3162097
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Abstract

High resolution diffusion tensor images of the mouse brain were acquired using the pulsed gradient spin echo sequence and the oscillating gradient spin echo sequence. The oscillating gradient spin echo tensor images demonstrated frequency‐dependent changes in diffusion measurements, including apparent diffusion coefficient and fractional anisotropy, in major brain structures. Maps of the rate of change in apparent diffusion coefficient with oscillating gradient frequency revealed novel tissue contrast in the mouse hippocampus, cerebellum, and cerebral cortex. The observed frequency‐dependent contrasts resembled neuronal soma‐specific Nissl staining and nuclei‐specific 4′,6‐diamidino‐2‐phenylindole (DAPI) staining in the mouse brain, which suggests that the contrasts might be related to key features of cytoarchitecture in the brain. In the mouse cuprizone model, oscillating gradient spin echo‐based diffusion MRI revealed significantly higher frequency‐dependence of perpendicular diffusivity (λ ⊥ ) in the demyelinated caudal corpus callosum at 4 weeks after cuprizone treatment when compared with control mice and mice at 6 weeks after cuprizone treatment. The elevated frequency‐dependence of λ ⊥ coincided with the infiltration of activated microglia/macrophages and disruption of axons during acute demyelination in the caudal corpus callosum. The results demonstrate the potential of oscillating gradient spin echo‐based diffusion MRI for providing tissue contrasts complimentary to conventional pulsed gradient spin echo‐based diffusion MRI. Magn Reson Med 67:98–109, 2012. © 2011 Wiley Periodicals, Inc.

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  • Demyelinated areas have extensive infiltration and amplification of cells that distort the normal tissue structure in the acute demyelination cuprizone model.

    “It’s reported that demyelinated areas have extensive infiltration and amplification of cells that distort the normal tissue structure in acute demyelination cuprizone model (Aggarwal et al. 2012; Sun et al. 2006).”

    From Neurite orientation dispersion and density imaging of mouse brain microstructure (2019) · cites this paper as Aggarwal et al. 2012

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Authors
Aggarwal, M., Jones, M. V., Calabresi, P. A., Mori, S., & Zhang, J.
Affiliations
  • Johns Hopkins University (US)
  • Kennedy Krieger Institute (US)
Corresponding author
Zhang, Jiangyang
ORCID
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2011-05-16
Volume
67
Issue
1
Pages
98-109
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.22981
PMC
PMC3162097
OpenAlex
W2103939073
Cited by
117
References
50
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 15 · 2019: 9 · 2018: 10 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 5
FWCI
4.61
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Multiple Sclerosis Society
  • National Institute on Aging (R01AG020012)
  • National Institute of Neurological Disorders and Stroke (R01NS070909, R21NS065306, R21NS059529)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB003543)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
oscillating gradient spin echo, diffusion MRI, apparent diffusion coefficient, fractional anisotropy, cuprizone demyelination, corpus callosum, hippocampus, cerebellum, cerebral cortex, cytoarchitecture, microglia/macrophage infiltration, axonal disruption, Nissl staining, DAPI staining
MeSH terms
Algorithms, Animals, Brain, Female, Image Enhancement, Image Interpretation, Computer-Assisted, Mice, Inbred C57BL, Oscillometry, Sensitivity and Specificity, Reproducibility of Results, Diffusion Magnetic Resonance Imaging, Mice

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