Evaluation of skeletal muscle during calf exercise by 31-phosphorus magnetic resonance spectroscopy in patients on statin medications
Open accessAbstract
Muscle pain is a common side effect of statin medications, but the cause is poorly understood. We characterized phosphocreatine (PCr) exercise recovery kinetics in 10 patients with hypercholesterolemia before and after a 4‐week regimen of statin therapy using 31‐phosphorus magnetic resonance spectroscopy (31 P‐MRS). 31 P spectra were obtained before, during, and after exercise on a calf flexion pedal ergometer. Creatine kinase (CK) serum levels were drawn before and after statin therapy. The mean metabolic recovery time constant in subjects increased from 28.1 s (SE = 6.5 s) to 55.4 s (SE = 7.4 s) after statin therapy. The unweighted mean of the pre/post‐recovery time difference was −27.3 s (SE = 12.4 s; P = 0.02). Pre‐ and post‐therapy CK levels were not significantly different (P = 0.50). Metabolic recovery time in the calf is prolonged in patients after statin use. This suggests that statins impair mitochondrial oxidative function, and 31 P MRS is a potential study model for statin‐associated myopathy. Muscle Nerve, 2011
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Post-exercise phosphocreatine recovery measured by 31-phosphorus magnetic resonance spectroscopy showed a prolonged recovery half-life during statin treatment even in the absence of any symptoms or overt CK changes.
“These measurements showed a prolonged recovery half-life during statin treatment even in the absence of any symptoms or overt CK changes.87”
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References 38 · Cited by 61
- Authors
- Wu, J. S., Buettner, C., Smithline, H., Ngo, L. H., & Greenman, R. L.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Baystate Medical Center (US)
- Corresponding author
- Wu, Jim S.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2010-12-17
- Volume
- 43
- Issue
- 1
- Pages
- 76-81
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- PMC
- PMC3332539
- OpenAlex
- W2017260179
- Cited by
- 61
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23AR055664)
- National Center for Research Resources (UL1RR025758)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- statin-induced myopathy, skeletal muscle, phosphocreatine, creatine kinase, hypercholesterolemia, statin therapy
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Muscular Diseases, Magnetic Resonance Spectroscopy, Phosphorus Isotopes, Exercise, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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