Motor unit firing pattern of vastus lateralis muscle in type 2 diabetes mellitus patients: Motor Unit Firing Pattern in Diabetes
Open accessAbstract
INTRODUCTION: We investigated the motor unit (MU) firing pattern in type 2 diabetes mellitus (T2DM) patients by means of multichannel surface electromyography (SEMG). METHODS: Eight T2DM patients and 8 age-matched, healthy men performed a ramp-up contraction to 20% of maximal voluntary contraction (MVC). They also performed a sustained contraction at 10% of MVC during isometric knee extension. Multichannel SEMG signals recorded from the vastus lateralis muscle were decomposed with the convolution kernel compensation technique to extract individual MU firing patterns. RESULTS: During the ramp contraction, the extent of MU firing modulation was significantly attenuated in T2DM. Variability of MU firing rate was significantly higher in T2DM at later periods during the sustained contraction. CONCLUSIONS: Our findings suggest that T2DM patients manifest characteristic MU activity patterns due possibly to some degree of neuromuscular impairment affecting the integrity of MU firing modulation.
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The procedures for calculating motor unit firing rates had been previously used in our studies.
“These procedures for calculating motor unit firing rates had been previously used in our studies (7,17,20).”
From Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults (2020) · cites this paper as [20]
Discharges with interdischarge intervals < 33.3 or >250 ms were excluded because firing rates calculated from this range are unusually high (>30 Hz) or low (<4 Hz) for the VL muscle.
“We excluded the discharges with interdischarge intervals < 33.3 or >250 ms because firing rates that calculated from this range of interdischarge intervals are unusually high (>30 Hz) or low (<4 Hz) for the VL muscle (7,20,21,30,31).”
From Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults (2020) · cites this paper as [20]
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References 49 · Cited by 58
- Authors
- Watanabe, K., Gazzoni, M., Holobar, A., Miyamoto, T., Fukuda, K., Merletti, R., & Moritani, T.
- Affiliations
- Kyoto University (JP)
- Politecnico di Torino (IT)
- Faculty of Electrical Engineering and Computer Science; University of Maribor; Maribor Slovenia
- University of Toyama (JP)
- Corresponding author
- Watanabe, Kohei
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2013-08-30
- Volume
- 48
- Issue
- 5
- Pages
- 806-813
- ISSN
- 0148-639X (ISSN-L)
- OpenAlex
- W1573906837
- Cited by
- 58
- References
- 49
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 10 · 2015: 4 · 2014: 7 · 2013: 2
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- PORTO@Iris (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (23300253, 24800071)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Keywords
- type 2 diabetes, motor unit firing patterns, vastus lateralis, surface electromyography, neuromuscular impairment, sustained contraction, isometric knee extension
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Electromyography, Humans, Knee, Male, Muscle Contraction, Recruitment, Neurophysiological, Quadriceps Muscle
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