Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 312

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review

Kemp, Graham J., Meyerspeer, Martin, Moser, Ewald·2007·NMR in Biomedicine
DOI 10.1002/nbm.1192
Open this paper in CoChat — free account

Abstract

31 P MRS offers a unique view of muscle metabolism in vivo, but correct quantification is important. Inter‐study correlation of estimates of [Pi] and [phosphocreatine (PCr)] in a number of published studies suggest that the main technical problem in calibrated 31 P MRS studies is the measurement of PCr and Pi signal intensities, rather than absolute quantification of [ATP]. For comparison, we discuss the few published biopsy studies of calf muscle and a selection of the many studies of quadriceps muscle. The ATP concentration is close to the value that we obtained in calf muscle in our own study, presented here, on four healthy subjects, by localised 31 P MRS using a surface coil incorporating an internal reference and calibrated using an external phantom. However, the freeze‐clamp biopsy PCr concentration is ∼20% lower than the value obtained by 31 P MRS, consistent with PCr breakdown by creatine kinase during freezing. Finally, we illustrate some consequences of uncertainty in resting [PCr] for analysis of mitochondrial function from PCr kinetics using a published 31 P MRS study of exercise and recovery: the lower the assumed resting [PCr], the lower the absolute rate of oxidative ATP synthesis estimated from the PCr resynthesis rate; in addition, the lower the assumed resting [PCr], or the higher the assumed [total creatine], the higher the apparent resting [ADP], and therefore the more sigmoid the relationship between the rate of oxidative ATP synthesis and [ADP]. Correct quantification of resting metabolite concentrations is crucially important for this sort of analysis. Our own results ([PCr] = 33 ± 2 mM, [Pi] = 4.5 ± 0.2 mM, and [ATP] = 8.2 ± 0.4 mM; mean ± SEM) are close to the overall mean values of the 10 published studies on calf muscle by ‘calibrated’ 31 P MRS (as in the present work), and of [PCr] and [Pi] in a representative selection of ‘uncalibrated’ 31 P MRS studies (i.e. from measured PCr/ATP and Pi/ATP ratios, assuming a literature value for [ATP]). Copyright © 2007 John Wiley & Sons, Ltd.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/nbm.1192

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Cited by

See all 312

Metadata

Authors
Kemp, G. J., Meyerspeer, M., & Moser, E.
Venue
NMR in Biomedicine
Publisher
Wiley
Published
2007-07-12
Volume
20
Issue
6
Pages
555-565
ISSN
  • 0952-3480 (ISSN-L)
  • 1099-1492
DOI
10.1002/nbm.1192
OpenAlex
W2112238233
Cited by
312
References
10
FWCI
9.12
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review. https://app.cochat.ai/papers/10.1002/nbm.1192
The paper
Kemp, G. J., Meyerspeer, M., & Moser, E. (2007). Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review. NMR in Biomedicine. https://doi.org/10.1002/nbm.1192

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.