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Manganese‐enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations
Abstract
Manganese‐enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connections in the brain; and to enhance the brain cytoarchitecture after a systemic dose. Based on an ever‐growing number of applications, MEMRI is proving useful as a new molecular imaging method to visualize functional neural circuits and anatomy as well as function in the brain in vivo. Paramount to the successful application of MEMRI is the ability to deliver Mn 2+ to the site of interest at an appropriate dose and in a time‐efficient manner. A major drawback to the use of Mn 2+ as a contrast agent is its cellular toxicity. Therefore, it is critical to use as low a dose as possible. In the present work the different approaches to MEMRI are reviewed from a practical standpoint. Emphasis is given to the experimental methodology of how to achieve significant, yet safe, amounts of Mn 2+ to the target areas of interest. Copyright © 2004 John Wiley & Sons, Ltd.
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Cited by
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“However, though MRI is non-destructive it is necessarily invasive and may be very injurious depending upon the method used (e.g., the manganese used in manganese-enhanced MRI is potentially toxic; Silva et al., 2004).”
MethodWeng, J.-C., Tikhonova, M. A., Chen, J.-H., Shen, M.-S., Meng, W.-Y., Chang, Y.-T., Chen, K.-H., Liang, K.-C., Hung, C.-S., Amstislavskaya, T. G., et al. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.02.034 · Cited by 39
Metadata
- Authors
- Silva, A. C., Lee, J. H., Aoki, I., & Koretsky, A. P.
- Venue
- NMR in Biomedicine
- Publisher
- Wiley
- Published
- 2004-11
- Volume
- 17
- Issue
- 8
- Pages
- 532-543
- ISSN
- 0952-3480 (ISSN-L)
- 1099-1492
- OpenAlex
- W2093360003
- Cited by
- 486
- References
- 0
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Silva, A. C., Lee, J. H., Aoki, I., & Koretsky, A. P. (2004). Manganese‐enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations. NMR in Biomedicine. https://doi.org/10.1002/nbm.945
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