Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: Reduction with weight loss: Obesity, Diabetes and Asthma
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OBJECTIVE: To determine whether the expression of key asthma related genes, IL-4, LIGHT, LTBR, MMP-9, CCR-2, and ADAM-33 in mononuclear cells and the plasma concentration of nitric oxide metabolites (NOM) and MMP-9 are increased in the obese, obese type 2 diabetics (T2DM) and in morbidly obese patients prior to and after gastric bypass surgery (RYGB). DESIGN AND METHODS: The expression of these genes in MNC and plasma concentrations of these indices was measured in healthy lean and in obese with and without T2DM and following RYGB in obese T2DM. RESULTS: The expression of IL-4, MMP-9, LIGHT and CCR-2 and plasma NOM concentrations was significantly higher in the obese subjects and in obese T2DM patients than in normal subjects. The expression of IL-4, LIGHT, MMP-9, and CCR-2 expression was related to BMI and HOMA-IR. The expression of IL-4, LIGHT, LTBR, ADAM-33, MMP-9, and CCR-2 fell after RYGB surgery as did plasma concentrations of MMP-9 and NOM. CONCLUSIONS: Obesity with and without T2DM is associated with an increase in the expression of IL-4, LIGHT, MMP-9 and CCR-2; plasma NOM and MMP-9 concentrations are also increased. Following RYGB surgery and weight loss, the expression of these factors in MNC and plasma concentrations falls significantly.
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Diabetes, hypertension, cardiovascular/renal/hepatic complications, hypogonadotropic hypogonadism, bronchial asthma, and Alzheimer's disease are associated with obesity.
“Several comorbidities such as diabetes, hypertension, cardiovascular/renal/hepatic complications, hypogonadotropic hypogonadism, bronchial asthma, and Alzheimer’s disease are associated with obesity [10-13].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [12]
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References 28 · Cited by 54
- Authors
- Dandona, P., Ghanim, H., Monte, S. V., Caruana, J. A., Green, K., Abuaysheh, S., Lohano, T., Schentag, J., Dhindsa, S., & Chaudhuri, A.
- Affiliations
- Kaleida Health (US)
- University at Buffalo, State University of New York (US)
- Sisters of Charity Hospital (US)
- Corresponding author
- Dandona, Paresh
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-09-04
- Volume
- 22
- Issue
- 2
- Pages
- 356-362
- ISSN
- 1930-7381 (ISSN-L)
- OpenAlex
- W1738740307
- Cited by
- 54
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 13 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Sanofi
- National Institutes of Health (5r01dk069805-04)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK069805, R01DK075877)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- asthma, type 2 diabetes, gastric bypass, weight loss, IL-4, light, lymphotoxin beta receptor, MMP-9, nitric oxide metabolites, mononuclear cells, insulin resistance, HOMA-IR
- MeSH terms
- Adult, Asthma, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Gene Expression Regulation, Humans, Insulin Resistance, Leukocytes, Mononuclear, Male, Middle Aged, Nitric Oxide, Obesity, Obesity, Morbid, Gastric Bypass, Weight Loss, Interleukin-4, Body Mass Index, Inflammation Mediators, Matrix Metalloproteinase 9, Tumor Necrosis Factor Ligand Superfamily Member 14, Receptors, CCR2
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