Changes in neural responsivity to highly palatable foods following roux‐en‐Y gastric bypass, sleeve gastrectomy, or weight stability: An f MRI study
Open accessAbstract
OBJECTIVE: This prospective, observational fMRI study examined changes over time in blood oxygen level dependent (BOLD) response to high- and low-calorie foods (HCF and LCF) in bariatric surgery candidates and weight-stable controls. METHODS: Twenty-two Roux-en-Y gastric bypass (RYGB) participants, 18 vertical sleeve gastrectomy (VSG) participants, and 19 weight-stable controls with severe obesity underwent fMRI before and 6 months after surgery/baseline. BOLD signal change in response to images of HCF vs. LCF was examined in a priori regions of interest. RESULTS: RYGB and VSG participants lost 23.6% and 21.1% of initial weight, respectively, at 6 months, and controls gained 1.0%. Liking ratings for HCF decreased significantly in the RYGB and VSG groups but remained stable in the control group. BOLD response in the ventral tegmental area (VTA) to HCF (vs. LCF) declined significantly more at 6 months in RYGB compared to control participants but not in VSG participants. Changes in fasting ghrelin correlated positively with changes in VTA BOLD signal in both RYGB and VSG but not in control participants. CONCLUSIONS: Results implicate the VTA as a critical site for modulating postsurgical changes in liking of highly palatable foods and suggest ghrelin as a potential substrate requiring further investigation.
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Compared to normal-weight control groups, those who have obesity have higher levels of reward-based eating.
“Some research has also suggested that, compared to normal-weight control groups, those who have obesity have higher levels of reward-based eating (45, 48–51).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [49]
The Introduction (page unavailable) reports differences in reward-pathway responses to food cues between people with and without obesity, but does not say that reward-based eating is higher in those with obesity. The study’s own control participants also had severe obesity, not normal weight (Introduction, page unavailable), so its Results cannot establish the claimed comparison. (LLM, conf=0.83)
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References 29 · Cited by 78
- Authors
- Faulconbridge, L. F., Ruparel, K., Loughead, J., Allison, K. C., Hesson, L. A., Fabricatore, A. N., Rochette, A., Ritter, S., Hopson, R. D., Sarwer, D. B., Williams, N. N., Geliebter, A., Gur, R. C., & Wadden, T. A.
- Affiliations
- University of Pennsylvania (US)
- Touro College (US)
- Corresponding author
- Faulconbridge, Lucy F.
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2016-04-25
- Volume
- 24
- Issue
- 5
- Pages
- 1054-1060
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC4866595
- OpenAlex
- W2345300910
- Cited by
- 78
- References
- 29
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 14 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 11 · 2016: 4
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Funders
- University of Pennsylvania
- Johns Hopkins University
- National Heart, Lung, and Blood Institute (K23HL109235)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080153, R01DK085615)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- Roux-en-Y gastric bypass, sleeve gastrectomy, bariatric surgery, palatability, food liking, ventral tegmental area, ghrelin, food reward, morbid obesity, weight loss
- MeSH terms
- Adult, Brain, Energy Intake, Female, Food, Gastrectomy, Humans, Magnetic Resonance Imaging, Male, Obesity, Morbid, Prospective Studies, Gastric Bypass, Weight Loss, Ventral Tegmental Area, Ghrelin, Young Adult
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