A genome-wide investigation of food addiction
Open accessAbstract
OBJECTIVE: Evidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction. It was hypothesized that a genome-wide association study (GWAS) of food addiction would yield significant enrichment in genes and pathways linked to addiction. METHODS: A GWAS of food addiction, determined by the modified Yale Food Addiction Scale (mYFAS), was conducted among 9,314 women of European ancestry, and results for enrichment of single-nucleotide polymorphisms (SNPs) (n = 44), genes (n = 238), and pathways (n = 11) implicated in drug addiction were examined. RESULTS: Two loci met GW-significance (P < 2.5 × 10(-8) ) mapping to 17q21.31 and 11q13.4 that harbor genes with no obvious roles in eating behavior. GW results were significantly enriched for gene members of the MAPK signaling pathway (P = 0.02). No candidate SNP or gene for drug addiction was significantly associated with food addiction after correction for multiple testing. CONCLUSIONS: In the first GWAS of mYFAS, suggestive loci worthy of further follow-up were identified, but limited support was provided for shared genetic underpinnings of food addiction and drug addiction. The latter might be due to limited study power and knowledge of the genetics of drug addiction.
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Genome wide association studies have found limited support for shared underpinnings for food addiction and substance use disorder.
“genome wide association studies have found limited support for shared underpinnings for FA and SUD [78]”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [78]
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References 41 · Cited by 44
- Authors
- Cornelis, M. C., Flint, A., Field, A. E., Kraft, P., Han, J., Rimm, E. B., & van Dam, R. M.
- Affiliations
- Northwestern University (US)
- Harvard University (US)
- Indiana University Indianapolis (US)
- Brigham and Women's Hospital (US)
- Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System Singapore Singapore
- Corresponding author
- Cornelis, Marilyn C.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2016-04-23
- Volume
- 24
- Issue
- 6
- Pages
- 1336-1341
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5038917
- OpenAlex
- W2336051871
- Cited by
- 44
- References
- 41
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (UL1TR001108, 5r01ca049449-18, 5p01dk070756-05)
- National Human Genome Research Institute (U01HG004399, U01HG004728)
- National Cancer Institute (R01CA040356, R01CA059045, R01‐CA049449, UM1CA176726, U01CA137088, U01CA098233, UM1CA186107, R01CA067262)
- National Institute on Deafness and Other Communication Disorders (R03DC013373)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-DK-070756)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- food addiction, drug addiction, shared genetic pathways, genome-wide association study, 17q21.31, MAPK signaling, single nucleotide polymorphisms, dietary habits
- MeSH terms
- Adult, Feeding Behavior, Female, Food, Humans, Middle Aged, Behavior, Addictive, Substance-Related Disorders, Polymorphism, Single Nucleotide, White People, Genome-Wide Association Study, Genetic Loci, Genotyping Techniques
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