Short‐ and Long‐Term Changes in Health‐Related Quality of Life with Weight Loss: Results from a Randomized Controlled Trial
Open accessAbstract
Objective: The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight‐specific health‐related quality of life in a 66‐week trial. Methods: Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14‐week intensive lifestyle intervention/low‐calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52‐week WLM program. The Impact of Weight on Quality of Life‐Lite (IWQOL‐Lite) scale (including five subscales), Patient Health Questionnaire‐9 (depression), and Perceived Stress Scale were administered at the start of the 14‐week LCD program, randomization, and week 52 of the randomized controlled trial (i.e., 66 weeks total). Results: Significant improvements in all outcomes, except weight‐related public distress, were found following the 14‐week LCD program (P values < 0.05). Improvements were largely maintained during the 52‐week randomized controlled trial, despite weight regain of 2.0 to 2.5 kg across treatment groups. Participants who lost ≥ 10% of initial weight achieved greater improvements in physical function, self‐esteem, sexual life, and the IWQOL‐Lite total score than those who lost < 5% and did not differ from those who lost 5% to 9.9%. Conclusions: Improvements in weight‐specific health‐related quality of life were achieved with moderate weight loss and were sustained during WLM.
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Greater weight loss reliably produces greater improvements in cardiometabolic risk factors and quality of life, as observed in the STEP trials.
“Greater weight loss reliably produces greater improvements in several cardiometabolic risk factors,(3) as well as quality of life,(41) as was observed in the STEP trials.”
From Semaglutide for the treatment of obesity (2023) · cites this paper as [41]
Psychosocial outcomes including quality of life and mood generally improve with behavioral weight reduction, with larger losses typically associated with greater benefits.
“Psychosocial outcomes including quality of life (QOL) and mood generally improve with behavioral weight reduction, with larger losses typically associated with greater benefits [110, 111].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [111]
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References 35 · Cited by 38
- Authors
- Pearl, R. L., Wadden, T. A., Tronieri, J. S., Berkowitz, R. I., Chao, A. M., Alamuddin, N., Leonard, S. M., Carvajal, R., Bakizada, Z. M., Pinkasavage, E., Gruber, K. A., Walsh, O. A., & Alfaris, N.
- Affiliations
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Center for Obesity Medicine Riyadh Saudi Arabia
- Corresponding author
- Pearl, Rebecca L.
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2018-04-20
- Volume
- 26
- Issue
- 6
- Pages
- 985-991
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5970047
- OpenAlex
- W2800048083
- Cited by
- 38
- References
- 35
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K23HL140176)
- National Institute of Nursing Research (T32NR007100)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
- Keywords
- weight loss, weight loss maintenance, health-related quality of life, lorcaserin, hypocaloric diet, lifestyle intervention, weight regain, IWQOL-Lite, depression, perceived stress, sexual function, self-esteem, physical function
- MeSH terms
- Adult, Behavior Therapy, Benzazepines, Counseling, Depression, Eating, Female, Humans, Life Style, Male, Mental Health, Middle Aged, Obesity, Quality of Life, Self Concept, Weight Loss, Anti-Obesity Agents, Caloric Restriction, Weight Reduction Programs
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